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Inhibition of Proliferation by PERK Regulates Mammary Acinar Morphogenesis and Tumor Formation
Endoplasmic reticulum (ER) stress signaling can be mediated by the ER kinase PERK, which phosphorylates its substrate eIF2α. This in turn, results in translational repression and the activation of downstream programs that can limit cell growth through cell cycle arrest and/or apoptosis. These respon...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1910610/ https://www.ncbi.nlm.nih.gov/pubmed/17637831 http://dx.doi.org/10.1371/journal.pone.0000615 |