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Modeling Insertional Mutagenesis Using Gene Length and Expression in Murine Embryonic Stem Cells

BACKGROUND: High-throughput mutagenesis of the mammalian genome is a powerful means to facilitate analysis of gene function. Gene trapping in embryonic stem cells (ESCs) is the most widely used form of insertional mutagenesis in mammals. However, the rules governing its efficiency are not fully unde...

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Detalles Bibliográficos
Autores principales:	Nord, Alex S., Vranizan, Karen, Tingley, Whittemore, Zambon, Alexander C., Hanspers, Kristina, Fong, Loren G., Hu, Yan, Bacchetti, Peter, Ferrin, Thomas E., Babbitt, Patricia C., Doniger, Scott W., Skarnes, William C., Young, Stephen G., Conklin, Bruce R.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1910612/ https://www.ncbi.nlm.nih.gov/pubmed/17637833 http://dx.doi.org/10.1371/journal.pone.0000617

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