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The adapter importin-α provides flexible control of nuclear import at the expense of efficiency

Although there exists a large family of nuclear transport receptors (Karyopherins), the majority of known import cargoes use an adapter protein, Importin-α (Impα), which links the cargo to a karyopherin, Importin-β (Impβ). The reason for the existence of transport adapters is unknown. One hypothesis...

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Detalles Bibliográficos
Autores principales: Riddick, Greg, Macara, Ian G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1911202/
https://www.ncbi.nlm.nih.gov/pubmed/17551513
http://dx.doi.org/10.1038/msb4100160