Sensitivity Analysis of Intracellular Signaling Pathway Kinetics Predicts Targets for Stem Cell Fate Control

Directing stem cell fate requires knowledge of how signaling networks integrate temporally and spatially segregated stimuli. We developed and validated a computational model of signal transducer and activator of transcription-3 (Stat3) pathway kinetics, a signaling network involved in embryonic stem...

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Detalles Bibliográficos
Autores principales: Mahdavi, Alborz, Davey, Ryan E, Bhola, Patrick, Yin, Ting, Zandstra, Peter W
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913098/
https://www.ncbi.nlm.nih.gov/pubmed/17616983
http://dx.doi.org/10.1371/journal.pcbi.0030130

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