DNA Damage, Homology-Directed Repair, and DNA Methylation

To explore the link between DNA damage and gene silencing, we induced a DNA double-strand break in the genome of Hela or mouse embryonic stem (ES) cells using I-SceI restriction endonuclease. The I-SceI site lies within one copy of two inactivated tandem repeated green fluorescent protein (GFP) gene...

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Detalles Bibliográficos
Autores principales: Cuozzo, Concetta, Porcellini, Antonio, Angrisano, Tiziana, Morano, Annalisa, Lee, Bongyong, Pardo, Alba Di, Messina, Samantha, Iuliano, Rodolfo, Fusco, Alfredo, Santillo, Maria R, Muller, Mark T, Chiariotti, Lorenzo, Gottesman, Max E, Avvedimento, Enrico V
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913100/
https://www.ncbi.nlm.nih.gov/pubmed/17616978
http://dx.doi.org/10.1371/journal.pgen.0030110

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