Formaldehyde at Low Concentration Induces Protein Tau into Globular Amyloid-Like Aggregates In Vitro and In Vivo

Recent studies have shown that neurodegeneration is closely related to misfolding and aggregation of neuronal tau. Our previous results show that neuronal tau aggregates in formaldehyde solution and that aggregated tau induces apoptosis of SH-SY5Y and hippocampal cells. In the present study, based o...

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Detalles Bibliográficos
Autores principales: Nie, Chun Lai, Wei, Yan, Chen, Xinyong, Liu, Yan Ying, Dui, Wen, Liu, Ying, Davies, Martyn C., Tendler, Saul J.B., He, Rong Giao
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913207/
https://www.ncbi.nlm.nih.gov/pubmed/17637844
http://dx.doi.org/10.1371/journal.pone.0000629

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