Cargando…

Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding

The copper(ii) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.

Detalles Bibliográficos
Autores principales:	Khan, Abid, Silversides, Jon D., Madden, Leigh, Greenman, John, Archibald, Stephen J.
Formato:	Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2007
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913474/ https://www.ncbi.nlm.nih.gov/pubmed/17220989 http://dx.doi.org/10.1039/b614557d

Ejemplares similares

Small-Molecule Fluorescent Ligands for the CXCR4 Chemokine Receptor
por: Dekkers, Sebastian, et al.
Publicado: (2023)

Exploratory Studies on Development of the Chemokine Receptor CXCR4 Antagonists Toward Downsizing
por: Tamamura, Hirokazu, et al.
Publicado: (2008)

Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t
por: Ward, Richard J., et al.
Publicado: (2020)

Copper(ii) cyclam-based complexes for radiopharmaceutical applications: synthesis and structural analysis
por: Silversides, Jon D., et al.
Publicado: (2007)

Mechanism of Peptide Agonist Binding in CXCR4 Chemokine Receptor
por: Pawnikar, Shristi, et al.
Publicado: (2022)

Fluorescent Ligands Enable Target Engagement Studies for the Intracellular Allosteric Binding Site of the Chemokine Receptor CXCR2
por: Huber, Max E., et al.
Publicado: (2023)

Design and synthesis of a bivalent probe targeting the putative mu opioid receptor and chemokine receptor CXCR4 heterodimer
por: Reinecke, Bethany A., et al.
Publicado: (2019)

Therapeutic Perspectives of HIV-Associated Chemokine Receptor (CCR5 and CXCR4) Antagonists in Carcinomas
por: González-Arriagada, Wilfredo Alejandro, et al.
Publicado: (2022)

Exploration of Pyrido[3,4-d]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2
por: Van Hoof, Max, et al.
Publicado: (2023)

Fluorescence Resonance Energy Transfer Imaging Reveals that Chemokine-Binding Modulates Heterodimers of CXCR4 and CCR5 Receptors
por: Isik, Nilgun, et al.
Publicado: (2008)

Agonists for the Chemokine Receptor CXCR4
por: Lefrançois, Marilou, et al.
Publicado: (2011)

Differences in Sulfotyrosine Binding amongst CXCR1 and CXCR2 Chemokine Ligands
por: Moussouras, Natasha A., et al.
Publicado: (2017)

Identification of Anti-Malarial Compounds as Novel Antagonists to Chemokine Receptor CXCR4 in Pancreatic Cancer Cells
por: Kim, Joseph, et al.
Publicado: (2012)

New imaging agents targeting chemokine receptor CXCR4 for PET/SPECT and MRI
por: Poty, Sophie, et al.
Publicado: (2014)

Specific Receptors for the Chemokines CXCR2 and CXCR4 in Pancreatic Cancer
por: Litman-Zawadzka, Ala, et al.
Publicado: (2020)

Control of cell migration in the development of the posterior lateral line: antagonistic interactions between the chemokine receptors CXCR4 and CXCR7/RDC1
por: Dambly-Chaudière, Christine, et al.
Publicado: (2007)

Regulation of the Chemokine Receptor CXCR4 by Hypoxia
por: Schioppa, Tiziana, et al.
Publicado: (2003)

Molecular Imaging of Chemokine Receptor CXCR4
por: Weiss, Ido. D., et al.
Publicado: (2013)

Dataset of (±)-NBI-74330 (CXCR3 antagonist) influence on chemokines under neuropathic pain
por: Piotrowska, Anna, et al.
Publicado: (2018)

Requirement of the Chemokine Receptor CXCR3 for Acute Allograft Rejection
por: Hancock, Wayne W., et al.
Publicado: (2000)

Chemokine receptors in the rheumatoid synovium: upregulation of CXCR5
por: Schmutz, Caroline, et al.
Publicado: (2005)

Structure of the Chemokine Receptor CXCR1 in Phospholipid Bilayers
por: Park, Sang Ho, et al.
Publicado: (2012)

Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes
por: Nojima, Hiroyuki, et al.
Publicado: (2016)

Impact of the Chemokine Receptors CXCR4 and CXCR7 on Clinical Outcome in Adrenocortical Carcinoma
por: Chifu, Irina, et al.
Publicado: (2020)

Computer‐aided assessment of the chemokine receptors CXCR3, CXCR4 and CXCR7 expression in gallbladder carcinoma
por: Yu, Xiao, et al.
Publicado: (2020)

Near-infrared molecular imaging of tumors via chemokine receptors CXCR4 and CXCR7
por: Meincke, Manuela, et al.
Publicado: (2011)

Improving the inhibitory effect of CXCR4 peptide antagonist in tumor metastasis with an acetylated PAMAM dendrimer
por: Liu, Changliang, et al.
Publicado: (2018)

The chemokine receptor CXCR4 is associated with the staging of gastric cancer
por: Nikzaban, Mehrnoush, et al.
Publicado: (2014)

The chemokine receptor CXCR2 and coronavirus-induced neurologic disease
por: Weinger, Jason G., et al.
Publicado: (2013)

The chemokine receptor CXCR2 contributes to murine adipocyte development
por: Dyer, Douglas P., et al.
Publicado: (2018)

The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion
por: Koenen, Andrea, et al.
Publicado: (2017)

The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration
por: Bianchi, Marco E., et al.
Publicado: (2020)

Structural Basis of the Binding Mode of the Antineoplastic Compound Motixafortide (BL-8040) in the CXCR4 Chemokine Receptor
por: Rebolledo-Bustillo, Mariana, et al.
Publicado: (2023)

The Chemokine Receptor CXCR6 Evokes Reverse Signaling via the Transmembrane Chemokine CXCL16
por: Adamski, Vivian, et al.
Publicado: (2017)

CCR5 and CXCR4 antagonist and agonist binding sites
por: Teintze, Martin, et al.
Publicado: (2006)

Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents
por: Che, Jinxin, et al.
Publicado: (2018)

Correction: Improving the inhibitory effect of CXCR4 peptide antagonist in tumor metastasis with an acetylated PAMAM dendrimer
por: Liu, Changliang, et al.
Publicado: (2019)

Correction: Improving the inhibitory effect of CXCR4 peptide antagonist in tumor metastasis with an acetylated PAMAM dendrimer
por: Liu, Changliang, et al.
Publicado: (2018)

Kinetic Analysis of the Early Signaling Steps of the Human Chemokine Receptor CXCR4
por: Perpiñá-Viciano, Cristina, et al.
Publicado: (2020)

Role of platelet-derived microparticles in transfer of the chemokine receptor CXCR4 to CXCR4-negative cells
por: Manoochehrabadi, Tahereh, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_otmvc79a71ti0ht322b7i2lgao