In silico screening of mutational effects on enzyme-proteic inhibitor affinity: a docking-based approach

BACKGROUND: Molecular recognition between enzymes and proteic inhibitors is crucial for normal functioning of many biological pathways. Mutations in either the enzyme or the inhibitor protein often lead to a modulation of the binding affinity with no major alterations in the 3D structure of the comp...

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Detalles Bibliográficos
Autores principales: Dell'Orco, Daniele, De Benedetti, Pier Giuseppe, Fanelli, Francesca
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913526/
https://www.ncbi.nlm.nih.gov/pubmed/17559675
http://dx.doi.org/10.1186/1472-6807-7-37

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913526/
https://www.ncbi.nlm.nih.gov/pubmed/17559675
http://dx.doi.org/10.1186/1472-6807-7-37

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