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In silico screening of mutational effects on enzyme-proteic inhibitor affinity: a docking-based approach
BACKGROUND: Molecular recognition between enzymes and proteic inhibitors is crucial for normal functioning of many biological pathways. Mutations in either the enzyme or the inhibitor protein often lead to a modulation of the binding affinity with no major alterations in the 3D structure of the comp...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913526/ https://www.ncbi.nlm.nih.gov/pubmed/17559675 http://dx.doi.org/10.1186/1472-6807-7-37 |