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Night Heart Rate Variability and Particulate Exposures among Boilermaker Construction Workers

BACKGROUND: Although studies have documented the association between heart rate variability (HRV) and ambient particulate exposures, the association between HRV, especially at night, and metal-rich, occupational particulate exposures remains unclear. OBJECTIVE: Our goal in this study was to investig...

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Autores principales: Cavallari, Jennifer M., Eisen, Ellen A., Chen, Jiu-Chiuan, Fang, Shona C., Dobson, Christine B., Schwartz, Joel, Christiani, David C.
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913585/
https://www.ncbi.nlm.nih.gov/pubmed/17637921
http://dx.doi.org/10.1289/ehp.10019
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author Cavallari, Jennifer M.
Eisen, Ellen A.
Chen, Jiu-Chiuan
Fang, Shona C.
Dobson, Christine B.
Schwartz, Joel
Christiani, David C.
author_facet Cavallari, Jennifer M.
Eisen, Ellen A.
Chen, Jiu-Chiuan
Fang, Shona C.
Dobson, Christine B.
Schwartz, Joel
Christiani, David C.
author_sort Cavallari, Jennifer M.
collection PubMed
description BACKGROUND: Although studies have documented the association between heart rate variability (HRV) and ambient particulate exposures, the association between HRV, especially at night, and metal-rich, occupational particulate exposures remains unclear. OBJECTIVE: Our goal in this study was to investigate the association between long-duration HRV, including nighttime HRV, and occupational PM(2.5) exposures. METHODS: We used 24-hr ambulatory electrocardiograms (ECGs) to monitor 36 male boilermaker welders (mean age of 41 years) over a workday and nonworkday. ECGs were analyzed for HRV in the time domain; rMSSD (square root of the mean squared differences of successive intervals), SDNN (SD of normal-to-normal intervals over entire recording), and SDNN(i) (SDNN for all 5-min segments) were summarized over 24-hr, day (0730–2130 hours), and night (0000–0700 hours) periods. PM(2.5) (particulate matter with an aerodynamic diameter ≤ 2.5 μm) exposures were monitored over the workday, and 8-hr time-weighted average concentrations were calculated. We used linear regression to assess the associations between HRV and workday particulate exposures. Matched measurements from a nonworkday were used to control for individual cardiac risk factors. RESULTS: Mean (± SD) PM(2.5) exposure was 0.73 ± 0.50 mg/m(3) and ranged from 0.04 to 2.70 mg/m(3). We observed a consistent inverse exposure–response relationship, with a decrease in all HRV measures with increased PM(2.5) exposure. However, the decrease was most pronounced at night, where a 1-mg/m(3) increase in PM(2.5) was associated with a change of −8.32 [95% confidence interval (CI), −16.29 to −0.35] msec nighttime rMSSD, −14.77 (95% CI, −31.52 to 1.97) msec nighttime SDNN, and −8.37 (95% CI, −17.93 to 1.20) msec nighttime SDNN(i), after adjusting for nonworking nighttime HRV, age, and smoking. CONCLUSION: Metal-rich particulate exposures were associated with decreased long-duration HRV, especially at night. Further research is needed to elucidate which particulate metal constituent is responsible for decreased HRV.
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spelling pubmed-19135852007-07-16 Night Heart Rate Variability and Particulate Exposures among Boilermaker Construction Workers Cavallari, Jennifer M. Eisen, Ellen A. Chen, Jiu-Chiuan Fang, Shona C. Dobson, Christine B. Schwartz, Joel Christiani, David C. Environ Health Perspect Research BACKGROUND: Although studies have documented the association between heart rate variability (HRV) and ambient particulate exposures, the association between HRV, especially at night, and metal-rich, occupational particulate exposures remains unclear. OBJECTIVE: Our goal in this study was to investigate the association between long-duration HRV, including nighttime HRV, and occupational PM(2.5) exposures. METHODS: We used 24-hr ambulatory electrocardiograms (ECGs) to monitor 36 male boilermaker welders (mean age of 41 years) over a workday and nonworkday. ECGs were analyzed for HRV in the time domain; rMSSD (square root of the mean squared differences of successive intervals), SDNN (SD of normal-to-normal intervals over entire recording), and SDNN(i) (SDNN for all 5-min segments) were summarized over 24-hr, day (0730–2130 hours), and night (0000–0700 hours) periods. PM(2.5) (particulate matter with an aerodynamic diameter ≤ 2.5 μm) exposures were monitored over the workday, and 8-hr time-weighted average concentrations were calculated. We used linear regression to assess the associations between HRV and workday particulate exposures. Matched measurements from a nonworkday were used to control for individual cardiac risk factors. RESULTS: Mean (± SD) PM(2.5) exposure was 0.73 ± 0.50 mg/m(3) and ranged from 0.04 to 2.70 mg/m(3). We observed a consistent inverse exposure–response relationship, with a decrease in all HRV measures with increased PM(2.5) exposure. However, the decrease was most pronounced at night, where a 1-mg/m(3) increase in PM(2.5) was associated with a change of −8.32 [95% confidence interval (CI), −16.29 to −0.35] msec nighttime rMSSD, −14.77 (95% CI, −31.52 to 1.97) msec nighttime SDNN, and −8.37 (95% CI, −17.93 to 1.20) msec nighttime SDNN(i), after adjusting for nonworking nighttime HRV, age, and smoking. CONCLUSION: Metal-rich particulate exposures were associated with decreased long-duration HRV, especially at night. Further research is needed to elucidate which particulate metal constituent is responsible for decreased HRV. National Institute of Environmental Health Sciences 2007-07 2007-04-05 /pmc/articles/PMC1913585/ /pubmed/17637921 http://dx.doi.org/10.1289/ehp.10019 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Cavallari, Jennifer M.
Eisen, Ellen A.
Chen, Jiu-Chiuan
Fang, Shona C.
Dobson, Christine B.
Schwartz, Joel
Christiani, David C.
Night Heart Rate Variability and Particulate Exposures among Boilermaker Construction Workers
title Night Heart Rate Variability and Particulate Exposures among Boilermaker Construction Workers
title_full Night Heart Rate Variability and Particulate Exposures among Boilermaker Construction Workers
title_fullStr Night Heart Rate Variability and Particulate Exposures among Boilermaker Construction Workers
title_full_unstemmed Night Heart Rate Variability and Particulate Exposures among Boilermaker Construction Workers
title_short Night Heart Rate Variability and Particulate Exposures among Boilermaker Construction Workers
title_sort night heart rate variability and particulate exposures among boilermaker construction workers
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913585/
https://www.ncbi.nlm.nih.gov/pubmed/17637921
http://dx.doi.org/10.1289/ehp.10019
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