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Association between Manganese Exposure through Drinking Water and Infant Mortality in Bangladesh
BACKGROUND: Manganese is a common natural contaminant of groundwater in Bangladesh. In this cross-sectional study we assessed the association between water manganese and all-cause infant mortality in the offspring of female participants in the Health Effects of Arsenic Longitudinal Study Cohort. MET...
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913599/ https://www.ncbi.nlm.nih.gov/pubmed/17637930 http://dx.doi.org/10.1289/ehp.10051 |
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author | Hafeman, Danella Factor-Litvak, Pam Cheng, Zhongqi van Geen, Alexander Ahsan, Habibul |
author_facet | Hafeman, Danella Factor-Litvak, Pam Cheng, Zhongqi van Geen, Alexander Ahsan, Habibul |
author_sort | Hafeman, Danella |
collection | PubMed |
description | BACKGROUND: Manganese is a common natural contaminant of groundwater in Bangladesh. In this cross-sectional study we assessed the association between water manganese and all-cause infant mortality in the offspring of female participants in the Health Effects of Arsenic Longitudinal Study Cohort. METHODS: In 2001, drinking water samples were collected, a history of well use was obtained, and a history of birth outcomes was ascertained. To avoid misclassification of exposure, women were included only if they had been drinking from the same well for most of their childbearing years (marriage years – well years ≤ 2). Of a total of 26,002 births (among 6,537 mothers), 3,837 children were born to women with this profile. The current analysis was based on the portion of these infants (n = 3,824) with recorded exposure and outcome status, 335 of whom died before reaching 1 year of age. RESULTS: Infants exposed to water manganese greater than or equal to the 2003 World Health Organization standard of 0.4 mg/L had an elevated mortality risk during the first year of life compared with unexposed infants [odds ratio (OR) = 1.8; 95% confidence interval (CI), 1.2–2.6]. Adjustment for water arsenic, indicators of social class, and other variables did not appreciably alter these results. When the population was restricted to infants born to recently married parents (marriage year 1991 or after), this elevation was more pronounced (OR = 3.4; 95% CI, 1.5–7.9). CONCLUSIONS: These preliminary findings indicate a possible association between manganese exposure and infant mortality. However, given the methodologic limitations of this study, the association needs to be confirmed through future work. |
format | Text |
id | pubmed-1913599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-19135992007-07-16 Association between Manganese Exposure through Drinking Water and Infant Mortality in Bangladesh Hafeman, Danella Factor-Litvak, Pam Cheng, Zhongqi van Geen, Alexander Ahsan, Habibul Environ Health Perspect Research BACKGROUND: Manganese is a common natural contaminant of groundwater in Bangladesh. In this cross-sectional study we assessed the association between water manganese and all-cause infant mortality in the offspring of female participants in the Health Effects of Arsenic Longitudinal Study Cohort. METHODS: In 2001, drinking water samples were collected, a history of well use was obtained, and a history of birth outcomes was ascertained. To avoid misclassification of exposure, women were included only if they had been drinking from the same well for most of their childbearing years (marriage years – well years ≤ 2). Of a total of 26,002 births (among 6,537 mothers), 3,837 children were born to women with this profile. The current analysis was based on the portion of these infants (n = 3,824) with recorded exposure and outcome status, 335 of whom died before reaching 1 year of age. RESULTS: Infants exposed to water manganese greater than or equal to the 2003 World Health Organization standard of 0.4 mg/L had an elevated mortality risk during the first year of life compared with unexposed infants [odds ratio (OR) = 1.8; 95% confidence interval (CI), 1.2–2.6]. Adjustment for water arsenic, indicators of social class, and other variables did not appreciably alter these results. When the population was restricted to infants born to recently married parents (marriage year 1991 or after), this elevation was more pronounced (OR = 3.4; 95% CI, 1.5–7.9). CONCLUSIONS: These preliminary findings indicate a possible association between manganese exposure and infant mortality. However, given the methodologic limitations of this study, the association needs to be confirmed through future work. National Institute of Environmental Health Sciences 2007-07 2007-03-27 /pmc/articles/PMC1913599/ /pubmed/17637930 http://dx.doi.org/10.1289/ehp.10051 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Hafeman, Danella Factor-Litvak, Pam Cheng, Zhongqi van Geen, Alexander Ahsan, Habibul Association between Manganese Exposure through Drinking Water and Infant Mortality in Bangladesh |
title | Association between Manganese Exposure through Drinking Water and Infant Mortality in Bangladesh |
title_full | Association between Manganese Exposure through Drinking Water and Infant Mortality in Bangladesh |
title_fullStr | Association between Manganese Exposure through Drinking Water and Infant Mortality in Bangladesh |
title_full_unstemmed | Association between Manganese Exposure through Drinking Water and Infant Mortality in Bangladesh |
title_short | Association between Manganese Exposure through Drinking Water and Infant Mortality in Bangladesh |
title_sort | association between manganese exposure through drinking water and infant mortality in bangladesh |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913599/ https://www.ncbi.nlm.nih.gov/pubmed/17637930 http://dx.doi.org/10.1289/ehp.10051 |
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