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Obesity Is A Modifier of Autonomic Cardiac Responses to Fine Metal Particulates
BACKGROUND: Increasing evidence suggests that obesity may impart greater susceptibility to adverse effects of air pollution. Particulate matter, especially PM(2.5) (particulate matter with aero-dynamic diameter ≤2.5 μm), is associated with increased cardiac events and reduction of heart rate variabi...
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913600/ https://www.ncbi.nlm.nih.gov/pubmed/17637913 http://dx.doi.org/10.1289/ehp.9609 |
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author | Chen, Jiu-Chiuan Cavallari, Jennifer M. Stone, Peter H. Christiani, David C. |
author_facet | Chen, Jiu-Chiuan Cavallari, Jennifer M. Stone, Peter H. Christiani, David C. |
author_sort | Chen, Jiu-Chiuan |
collection | PubMed |
description | BACKGROUND: Increasing evidence suggests that obesity may impart greater susceptibility to adverse effects of air pollution. Particulate matter, especially PM(2.5) (particulate matter with aero-dynamic diameter ≤2.5 μm), is associated with increased cardiac events and reduction of heart rate variability (HRV). OBJECTIVES: Our goal was to investigate whether particle-mediated autonomic modulation is aggravated in obese individuals. METHODS: We examined PM(2.5)-mediated acute effects on HRV and heart rate (HR) using 10 24-hr and 13 48-hr ambulatory electrocardiogram recordings collected from 18 boilermakers (39.5 ± 9.1 years of age) exposed to high levels of metal particulates. Average HR and 5-min HRV [SDNN: standard deviation of normal-to-normal intervals (NN); rMSSD: square-root of mean squared-differences of successive NN intervals; HF: high-frequency power 0.15–0.4 Hz] and personal PM(2.5) exposures were continuously monitored. Subjects with body mass index ≥ 30 kg/m(2) were classified as obese. Mixed-effect models were used for statistical analyses. RESULTS: Half (50%) of the study subjects were obese. After adjustment for confounders, each 1-mg/m(3) increase in 4-hr moving average PM(2.5) was associated with HR increase of 5.9 bpm [95% confidence interval (CI), 4.2 to 7.7] and with 5-min HRV reduction by 6.5% (95% CI, 1.9 to 11.3%) for SDNN, 1.7% (95% CI, –4.9 to 8.4%) for rMSSD, and 8.8% (95% CI, –3.8 to 21.3%) for HF. Obese individuals had greater PM(2.5)-mediated HRV reductions (2- to 3-fold differences) than nonobese individuals, and had more PM(2.5)-mediated HR increases (9-bpm vs. 4-bpm increase in HR for each 1-mg/m(3) increase in PM(2.5); p < 0.001). CONCLUSIONS: Our study revealed greater autonomic cardiac responses to metal particulates in obese workers, supporting the hypothesis that obesity may impart greater susceptibility to acute cardiovascular effects of fine particles. |
format | Text |
id | pubmed-1913600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-19136002007-07-16 Obesity Is A Modifier of Autonomic Cardiac Responses to Fine Metal Particulates Chen, Jiu-Chiuan Cavallari, Jennifer M. Stone, Peter H. Christiani, David C. Environ Health Perspect Research BACKGROUND: Increasing evidence suggests that obesity may impart greater susceptibility to adverse effects of air pollution. Particulate matter, especially PM(2.5) (particulate matter with aero-dynamic diameter ≤2.5 μm), is associated with increased cardiac events and reduction of heart rate variability (HRV). OBJECTIVES: Our goal was to investigate whether particle-mediated autonomic modulation is aggravated in obese individuals. METHODS: We examined PM(2.5)-mediated acute effects on HRV and heart rate (HR) using 10 24-hr and 13 48-hr ambulatory electrocardiogram recordings collected from 18 boilermakers (39.5 ± 9.1 years of age) exposed to high levels of metal particulates. Average HR and 5-min HRV [SDNN: standard deviation of normal-to-normal intervals (NN); rMSSD: square-root of mean squared-differences of successive NN intervals; HF: high-frequency power 0.15–0.4 Hz] and personal PM(2.5) exposures were continuously monitored. Subjects with body mass index ≥ 30 kg/m(2) were classified as obese. Mixed-effect models were used for statistical analyses. RESULTS: Half (50%) of the study subjects were obese. After adjustment for confounders, each 1-mg/m(3) increase in 4-hr moving average PM(2.5) was associated with HR increase of 5.9 bpm [95% confidence interval (CI), 4.2 to 7.7] and with 5-min HRV reduction by 6.5% (95% CI, 1.9 to 11.3%) for SDNN, 1.7% (95% CI, –4.9 to 8.4%) for rMSSD, and 8.8% (95% CI, –3.8 to 21.3%) for HF. Obese individuals had greater PM(2.5)-mediated HRV reductions (2- to 3-fold differences) than nonobese individuals, and had more PM(2.5)-mediated HR increases (9-bpm vs. 4-bpm increase in HR for each 1-mg/m(3) increase in PM(2.5); p < 0.001). CONCLUSIONS: Our study revealed greater autonomic cardiac responses to metal particulates in obese workers, supporting the hypothesis that obesity may impart greater susceptibility to acute cardiovascular effects of fine particles. National Institute of Environmental Health Sciences 2007-07 2007-02-26 /pmc/articles/PMC1913600/ /pubmed/17637913 http://dx.doi.org/10.1289/ehp.9609 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Chen, Jiu-Chiuan Cavallari, Jennifer M. Stone, Peter H. Christiani, David C. Obesity Is A Modifier of Autonomic Cardiac Responses to Fine Metal Particulates |
title | Obesity Is A Modifier of Autonomic Cardiac Responses to Fine Metal Particulates |
title_full | Obesity Is A Modifier of Autonomic Cardiac Responses to Fine Metal Particulates |
title_fullStr | Obesity Is A Modifier of Autonomic Cardiac Responses to Fine Metal Particulates |
title_full_unstemmed | Obesity Is A Modifier of Autonomic Cardiac Responses to Fine Metal Particulates |
title_short | Obesity Is A Modifier of Autonomic Cardiac Responses to Fine Metal Particulates |
title_sort | obesity is a modifier of autonomic cardiac responses to fine metal particulates |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913600/ https://www.ncbi.nlm.nih.gov/pubmed/17637913 http://dx.doi.org/10.1289/ehp.9609 |
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