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HIV-1 Vpr-Mediated G2 Arrest Involves the DDB1-CUL4A(VPRBP) E3 Ubiquitin Ligase

Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has been shown to cause G2 cell cycle arrest in human cells by inducing ATR-mediated inactivation of p34cdc2, but factors directly engaged in this process remain unknown. We used tandem affinity purification to isolate native Vpr comp...

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Detalles Bibliográficos
Autores principales:	Belzile, Jean-Philippe, Duisit, Ghislaine, Rougeau, Nicole, Mercier, Johanne, Finzi, Andrés, Cohen, Éric A
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914068/ https://www.ncbi.nlm.nih.gov/pubmed/17630831 http://dx.doi.org/10.1371/journal.ppat.0030085

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