Cargando…

Non-Radical Diagnostic Biopsies Do Not Negatively Influence Melanoma Patient Survival

BACKGROUND: In fair-skinned Caucasian populations both the incidence and mortality rates of cutaneous melanoma have been increasing over the past decades. With adjuvant therapies still being under investigation, early detection is the only way to improve melanoma patient survival. The influence of i...

Descripción completa

Detalles Bibliográficos
Autores principales: Molenkamp, Barbara G., Sluijter, Berbel J. R., Oosterhof, Benny, Meijer, Sybren, van Leeuwen, Paul A. M.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914261/
https://www.ncbi.nlm.nih.gov/pubmed/17225977
http://dx.doi.org/10.1245/s10434-006-9302-7
_version_ 1782134115107078144
author Molenkamp, Barbara G.
Sluijter, Berbel J. R.
Oosterhof, Benny
Meijer, Sybren
van Leeuwen, Paul A. M.
author_facet Molenkamp, Barbara G.
Sluijter, Berbel J. R.
Oosterhof, Benny
Meijer, Sybren
van Leeuwen, Paul A. M.
author_sort Molenkamp, Barbara G.
collection PubMed
description BACKGROUND: In fair-skinned Caucasian populations both the incidence and mortality rates of cutaneous melanoma have been increasing over the past decades. With adjuvant therapies still being under investigation, early detection is the only way to improve melanoma patient survival. The influence of incisional biopsies on melanoma patient survival has been discussed for many years. This study investigates both the influence of diagnostic biopsy type and the presence of residual tumor cells in the re-excision specimen on disease free and overall survival. METHODS: After (partial) removal of a pigmented skin lesion 471 patients were diagnosed with stage I/II melanoma and underwent re-excision and a sentinel node biopsy. All patients were followed prospectively, mean follow up >5 years. Patients were divided according to their diagnostic biopsy type (wide excision biopsy, narrow excision biopsy, excision biopsy with positive margins and incisional biopsy) and the presence of residual tumor cells in their re-excision specimen. Survival analysis was done using Cox’s proportional hazard model adjusted for eight important confounders of melanoma patient survival. RESULTS: The diagnostic biopsy was wide in 279 patients, narrow in 109 patients, 52 patients underwent an excision biopsy with positive margins and 31 patients an incisional biopsy. In 41 patients residual tumor cells were present in the re-excision specimen. Both the diagnostic biopsy type and the presence of tumor cells in the re-excision specimen did not influence disease free and overall survival of melanoma patients. CONCLUSIONS: Non-radical diagnostic biopsies do not negatively influence melanoma patient survival.
format Text
id pubmed-1914261
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Springer-Verlag
record_format MEDLINE/PubMed
spelling pubmed-19142612007-07-12 Non-Radical Diagnostic Biopsies Do Not Negatively Influence Melanoma Patient Survival Molenkamp, Barbara G. Sluijter, Berbel J. R. Oosterhof, Benny Meijer, Sybren van Leeuwen, Paul A. M. Ann Surg Oncol Article BACKGROUND: In fair-skinned Caucasian populations both the incidence and mortality rates of cutaneous melanoma have been increasing over the past decades. With adjuvant therapies still being under investigation, early detection is the only way to improve melanoma patient survival. The influence of incisional biopsies on melanoma patient survival has been discussed for many years. This study investigates both the influence of diagnostic biopsy type and the presence of residual tumor cells in the re-excision specimen on disease free and overall survival. METHODS: After (partial) removal of a pigmented skin lesion 471 patients were diagnosed with stage I/II melanoma and underwent re-excision and a sentinel node biopsy. All patients were followed prospectively, mean follow up >5 years. Patients were divided according to their diagnostic biopsy type (wide excision biopsy, narrow excision biopsy, excision biopsy with positive margins and incisional biopsy) and the presence of residual tumor cells in their re-excision specimen. Survival analysis was done using Cox’s proportional hazard model adjusted for eight important confounders of melanoma patient survival. RESULTS: The diagnostic biopsy was wide in 279 patients, narrow in 109 patients, 52 patients underwent an excision biopsy with positive margins and 31 patients an incisional biopsy. In 41 patients residual tumor cells were present in the re-excision specimen. Both the diagnostic biopsy type and the presence of tumor cells in the re-excision specimen did not influence disease free and overall survival of melanoma patients. CONCLUSIONS: Non-radical diagnostic biopsies do not negatively influence melanoma patient survival. Springer-Verlag 2007-01-17 2007-04 /pmc/articles/PMC1914261/ /pubmed/17225977 http://dx.doi.org/10.1245/s10434-006-9302-7 Text en © Society of Surgical Oncology 2006
spellingShingle Article
Molenkamp, Barbara G.
Sluijter, Berbel J. R.
Oosterhof, Benny
Meijer, Sybren
van Leeuwen, Paul A. M.
Non-Radical Diagnostic Biopsies Do Not Negatively Influence Melanoma Patient Survival
title Non-Radical Diagnostic Biopsies Do Not Negatively Influence Melanoma Patient Survival
title_full Non-Radical Diagnostic Biopsies Do Not Negatively Influence Melanoma Patient Survival
title_fullStr Non-Radical Diagnostic Biopsies Do Not Negatively Influence Melanoma Patient Survival
title_full_unstemmed Non-Radical Diagnostic Biopsies Do Not Negatively Influence Melanoma Patient Survival
title_short Non-Radical Diagnostic Biopsies Do Not Negatively Influence Melanoma Patient Survival
title_sort non-radical diagnostic biopsies do not negatively influence melanoma patient survival
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914261/
https://www.ncbi.nlm.nih.gov/pubmed/17225977
http://dx.doi.org/10.1245/s10434-006-9302-7
work_keys_str_mv AT molenkampbarbarag nonradicaldiagnosticbiopsiesdonotnegativelyinfluencemelanomapatientsurvival
AT sluijterberbeljr nonradicaldiagnosticbiopsiesdonotnegativelyinfluencemelanomapatientsurvival
AT oosterhofbenny nonradicaldiagnosticbiopsiesdonotnegativelyinfluencemelanomapatientsurvival
AT meijersybren nonradicaldiagnosticbiopsiesdonotnegativelyinfluencemelanomapatientsurvival
AT vanleeuwenpaulam nonradicaldiagnosticbiopsiesdonotnegativelyinfluencemelanomapatientsurvival