Linkage study of 14 candidate genes and loci in four large Dutch families with vesico-ureteral reflux

Vesico-ureteral reflux (VUR) is a major contributing factor to end-stage renal disease in paediatric patients. Primary VUR is a familial disorder, but little is known about its genetic causes. To investigate the involvement of 12 functional candidate genes and two reported loci in VUR, we performed...

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Autores principales: van Eerde, Albertien M., Koeleman, Bobby P. C., van de Kamp, Jiddeke M., de Jong, Tom P. V. M., Wijmenga, Cisca, Giltay, Jacques C.
Formato: Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2007
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1915619/
https://www.ncbi.nlm.nih.gov/pubmed/17497182
http://dx.doi.org/10.1007/s00467-007-0492-4
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author van Eerde, Albertien M.
Koeleman, Bobby P. C.
van de Kamp, Jiddeke M.
de Jong, Tom P. V. M.
Wijmenga, Cisca
Giltay, Jacques C.
author_facet van Eerde, Albertien M.
Koeleman, Bobby P. C.
van de Kamp, Jiddeke M.
de Jong, Tom P. V. M.
Wijmenga, Cisca
Giltay, Jacques C.
author_sort van Eerde, Albertien M.
collection PubMed
description Vesico-ureteral reflux (VUR) is a major contributing factor to end-stage renal disease in paediatric patients. Primary VUR is a familial disorder, but little is known about its genetic causes. To investigate the involvement of 12 functional candidate genes and two reported loci in VUR, we performed a linkage study in four large, Dutch, multi-generational families with multiple affected individuals. We were unable to detect linkage to any of the genes and loci and could exclude the GDNF, RET, SLIT2, SPRY1, PAX2, AGTR2, UPK1A and UPK3A genes and the 1p13 and 20p13 loci from linkage to VUR. Our results provide further evidence that there appears to be genetic heterogeneity in VUR. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00467-007-0492-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-19156192007-07-13 Linkage study of 14 candidate genes and loci in four large Dutch families with vesico-ureteral reflux van Eerde, Albertien M. Koeleman, Bobby P. C. van de Kamp, Jiddeke M. de Jong, Tom P. V. M. Wijmenga, Cisca Giltay, Jacques C. Pediatr Nephrol Original Article Vesico-ureteral reflux (VUR) is a major contributing factor to end-stage renal disease in paediatric patients. Primary VUR is a familial disorder, but little is known about its genetic causes. To investigate the involvement of 12 functional candidate genes and two reported loci in VUR, we performed a linkage study in four large, Dutch, multi-generational families with multiple affected individuals. We were unable to detect linkage to any of the genes and loci and could exclude the GDNF, RET, SLIT2, SPRY1, PAX2, AGTR2, UPK1A and UPK3A genes and the 1p13 and 20p13 loci from linkage to VUR. Our results provide further evidence that there appears to be genetic heterogeneity in VUR. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00467-007-0492-4) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2007-08-01 2007 /pmc/articles/PMC1915619/ /pubmed/17497182 http://dx.doi.org/10.1007/s00467-007-0492-4 Text en © IPNA 2007 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
van Eerde, Albertien M.
Koeleman, Bobby P. C.
van de Kamp, Jiddeke M.
de Jong, Tom P. V. M.
Wijmenga, Cisca
Giltay, Jacques C.
Linkage study of 14 candidate genes and loci in four large Dutch families with vesico-ureteral reflux
title Linkage study of 14 candidate genes and loci in four large Dutch families with vesico-ureteral reflux
title_full Linkage study of 14 candidate genes and loci in four large Dutch families with vesico-ureteral reflux
title_fullStr Linkage study of 14 candidate genes and loci in four large Dutch families with vesico-ureteral reflux
title_full_unstemmed Linkage study of 14 candidate genes and loci in four large Dutch families with vesico-ureteral reflux
title_short Linkage study of 14 candidate genes and loci in four large Dutch families with vesico-ureteral reflux
title_sort linkage study of 14 candidate genes and loci in four large dutch families with vesico-ureteral reflux
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1915619/
https://www.ncbi.nlm.nih.gov/pubmed/17497182
http://dx.doi.org/10.1007/s00467-007-0492-4
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