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ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke
BACKGROUND: In response to DNA damage or structural alterations of chromatin, histone H2AX may be phosphorylated on Ser139 by phosphoinositide 3-kinase related protein kinases (PIKKs) such as ataxia telangiectasia mutated (ATM), ATM-and Rad-3 related (ATR) kinase, or by DNA dependent protein kinase...
Autores principales: | Tanaka, Toshiki, Huang, Xuan, Jorgensen, Ellen, Gietl, Diana, Traganos, Frank, Darzynkiewicz, Zbigniew, Albino, Anthony P |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1919366/ https://www.ncbi.nlm.nih.gov/pubmed/17594478 http://dx.doi.org/10.1186/1471-2121-8-26 |
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