Simple PCR Assays Improve the Sensitivity of HIV-1 Subtype B Drug Resistance Testing and Allow Linking of Resistance Mutations

BACKGROUND: The success of antiretroviral therapy is known to be compromised by drug-resistant HIV-1 at frequencies detectable by conventional bulk sequencing. Currently, there is a need to assess the clinical consequences of low-frequency drug resistant variants occurring below the detection limit...

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Detalles Bibliográficos
Autores principales: Johnson, Jeffrey A., Li, Jin-Fen, Wei, Xierong, Lipscomb, Jonathan, Bennett, Diane, Brant, Ashley, Cong, Mian-er, Spira, Thomas, Shafer, Robert W., Heneine, Walid
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1919426/
https://www.ncbi.nlm.nih.gov/pubmed/17653265
http://dx.doi.org/10.1371/journal.pone.0000638

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