Effects of nucleic acid local structure and magnesium ions on minus-strand transfer mediated by the nucleic acid chaperone activity of HIV-1 nucleocapsid protein

HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone, which is required for highly specific and efficient reverse transcription. Here, we demonstrate that local structure of acceptor RNA at a potential nucleation site, rather than overall thermodynamic stability, is a critical determinant for...

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Detalles Bibliográficos
Autores principales: Wu, Tiyun, Heilman-Miller, Susan L., Levin, Judith G.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1919501/
https://www.ncbi.nlm.nih.gov/pubmed/17553835
http://dx.doi.org/10.1093/nar/gkm375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1919501/
https://www.ncbi.nlm.nih.gov/pubmed/17553835
http://dx.doi.org/10.1093/nar/gkm375

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