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Human RNase P: a tRNA-processing enzyme and transcription factor
Ribonuclease P (RNase P) has been hitherto well known as a catalytic ribonucleoprotein that processes the 5′ leader sequence of precursor tRNA. Recent studies, however, reveal a new role for nuclear forms of RNase P in the transcription of tRNA genes by RNA polymerase (pol) III, thus linking transcr...
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920233/ https://www.ncbi.nlm.nih.gov/pubmed/17483522 http://dx.doi.org/10.1093/nar/gkm071 |
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author | Jarrous, Nayef Reiner, Robert |
author_facet | Jarrous, Nayef Reiner, Robert |
author_sort | Jarrous, Nayef |
collection | PubMed |
description | Ribonuclease P (RNase P) has been hitherto well known as a catalytic ribonucleoprotein that processes the 5′ leader sequence of precursor tRNA. Recent studies, however, reveal a new role for nuclear forms of RNase P in the transcription of tRNA genes by RNA polymerase (pol) III, thus linking transcription with processing in the regulation of tRNA gene expression. However, RNase P is also essential for the transcription of other small noncoding RNA genes, whose precursor transcripts are not recognized as substrates for this holoenzyme. Accordingly, RNase P can act solely as a transcription factor for pol III, a role that seems to be conserved in eukarya. |
format | Text |
id | pubmed-1920233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-19202332007-07-19 Human RNase P: a tRNA-processing enzyme and transcription factor Jarrous, Nayef Reiner, Robert Nucleic Acids Res Survey and Summary Ribonuclease P (RNase P) has been hitherto well known as a catalytic ribonucleoprotein that processes the 5′ leader sequence of precursor tRNA. Recent studies, however, reveal a new role for nuclear forms of RNase P in the transcription of tRNA genes by RNA polymerase (pol) III, thus linking transcription with processing in the regulation of tRNA gene expression. However, RNase P is also essential for the transcription of other small noncoding RNA genes, whose precursor transcripts are not recognized as substrates for this holoenzyme. Accordingly, RNase P can act solely as a transcription factor for pol III, a role that seems to be conserved in eukarya. Oxford University Press 2007-06 2007-05-05 /pmc/articles/PMC1920233/ /pubmed/17483522 http://dx.doi.org/10.1093/nar/gkm071 Text en © 2007 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Survey and Summary Jarrous, Nayef Reiner, Robert Human RNase P: a tRNA-processing enzyme and transcription factor |
title | Human RNase P: a tRNA-processing enzyme and transcription factor |
title_full | Human RNase P: a tRNA-processing enzyme and transcription factor |
title_fullStr | Human RNase P: a tRNA-processing enzyme and transcription factor |
title_full_unstemmed | Human RNase P: a tRNA-processing enzyme and transcription factor |
title_short | Human RNase P: a tRNA-processing enzyme and transcription factor |
title_sort | human rnase p: a trna-processing enzyme and transcription factor |
topic | Survey and Summary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920233/ https://www.ncbi.nlm.nih.gov/pubmed/17483522 http://dx.doi.org/10.1093/nar/gkm071 |
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