Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome

Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C-cells which can secrete adrenocorticotropic hormone (ACTH) and/or corticotropin-releasing factor (CRF) in abnormally high concentrations, potentially causing paraneoplastic Cushing...

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Autores principales: Sand, Michael, Uecker, Samuel, Bechara, Falk G, Gelos, Marcos, Sand, Daniel, Wiese, Till H, Mann, Benno
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920524/
https://www.ncbi.nlm.nih.gov/pubmed/17605812
http://dx.doi.org/10.1186/1477-7800-4-15
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author Sand, Michael
Uecker, Samuel
Bechara, Falk G
Gelos, Marcos
Sand, Daniel
Wiese, Till H
Mann, Benno
author_facet Sand, Michael
Uecker, Samuel
Bechara, Falk G
Gelos, Marcos
Sand, Daniel
Wiese, Till H
Mann, Benno
author_sort Sand, Michael
collection PubMed
description Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C-cells which can secrete adrenocorticotropic hormone (ACTH) and/or corticotropin-releasing factor (CRF) in abnormally high concentrations, potentially causing paraneoplastic Cushing's Syndrome (CS). We report on a 42-year-old male patient with a ten year history of metastatic medullary thyroid carcinoma suffering from paraneoplastic Cushing's Syndrome caused by ectopic hypersecretion of ACTH and a simultaneous Cortisol producing adrenal metastasis.
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spelling pubmed-19205242007-07-17 Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome Sand, Michael Uecker, Samuel Bechara, Falk G Gelos, Marcos Sand, Daniel Wiese, Till H Mann, Benno Int Semin Surg Oncol Case Report Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C-cells which can secrete adrenocorticotropic hormone (ACTH) and/or corticotropin-releasing factor (CRF) in abnormally high concentrations, potentially causing paraneoplastic Cushing's Syndrome (CS). We report on a 42-year-old male patient with a ten year history of metastatic medullary thyroid carcinoma suffering from paraneoplastic Cushing's Syndrome caused by ectopic hypersecretion of ACTH and a simultaneous Cortisol producing adrenal metastasis. BioMed Central 2007-07-02 /pmc/articles/PMC1920524/ /pubmed/17605812 http://dx.doi.org/10.1186/1477-7800-4-15 Text en Copyright © 2007 Sand et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sand, Michael
Uecker, Samuel
Bechara, Falk G
Gelos, Marcos
Sand, Daniel
Wiese, Till H
Mann, Benno
Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome
title Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome
title_full Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome
title_fullStr Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome
title_full_unstemmed Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome
title_short Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome
title_sort simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic cushing's syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920524/
https://www.ncbi.nlm.nih.gov/pubmed/17605812
http://dx.doi.org/10.1186/1477-7800-4-15
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