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p53 Target Gene SMAR1 Is Dysregulated in Breast Cancer: Its Role in Cancer Cell Migration and Invasion

Tumor suppressor SMAR1 interacts and stabilizes p53 through phosphorylation at its serine-15 residue. We show that SMAR1 transcription is regulated by p53 through its response element present in the SMAR1 promoter. Upon Doxorubicin induced DNA damage, acetylated p53 is recruited on SMAR1 promoter th...

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Detalles Bibliográficos
Autores principales:	Singh, Kamini, Mogare, Devraj, Giridharagopalan, Ramprasad Obula, Gogiraju, Rajinikanth, Pande, Gopal, Chattopadhyay, Samit
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924604/ https://www.ncbi.nlm.nih.gov/pubmed/17668048 http://dx.doi.org/10.1371/journal.pone.0000660

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