Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain

BACKGROUND: Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported in which to examine infection kinetics and natural dissemination to the brain. METHODS: Five mouse lin...

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Autores principales: Wickham, Mark E, Brown, Nat F, Provias, John, Finlay, B Brett, Coombes, Brian K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1925087/
https://www.ncbi.nlm.nih.gov/pubmed/17597539
http://dx.doi.org/10.1186/1471-2334-7-65
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author Wickham, Mark E
Brown, Nat F
Provias, John
Finlay, B Brett
Coombes, Brian K
author_facet Wickham, Mark E
Brown, Nat F
Provias, John
Finlay, B Brett
Coombes, Brian K
author_sort Wickham, Mark E
collection PubMed
description BACKGROUND: Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported in which to examine infection kinetics and natural dissemination to the brain. METHODS: Five mouse lines including C57BL/6, Balb/c, 129S6-Slc11a1tm1(Mcg), 129S1/SvImJ, B6.129-Inpp5dtm1(Rkh )were used in the murine typhoid model to examine the dissemination of systemic Salmonella enterica serovar Typhimurium following oral infection. RESULTS: We report data on spontaneous meningitis and brain infection following oral infection of mice with Salmonella enterica serovar Typhimurium. CONCLUSION: This model may provide a system in which dissemination of bacteria through the central nervous system and the influence of host and bacterial genetics can be queried.
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spelling pubmed-19250872007-07-20 Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain Wickham, Mark E Brown, Nat F Provias, John Finlay, B Brett Coombes, Brian K BMC Infect Dis Research Article BACKGROUND: Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported in which to examine infection kinetics and natural dissemination to the brain. METHODS: Five mouse lines including C57BL/6, Balb/c, 129S6-Slc11a1tm1(Mcg), 129S1/SvImJ, B6.129-Inpp5dtm1(Rkh )were used in the murine typhoid model to examine the dissemination of systemic Salmonella enterica serovar Typhimurium following oral infection. RESULTS: We report data on spontaneous meningitis and brain infection following oral infection of mice with Salmonella enterica serovar Typhimurium. CONCLUSION: This model may provide a system in which dissemination of bacteria through the central nervous system and the influence of host and bacterial genetics can be queried. BioMed Central 2007-06-27 /pmc/articles/PMC1925087/ /pubmed/17597539 http://dx.doi.org/10.1186/1471-2334-7-65 Text en Copyright © 2007 Wickham et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wickham, Mark E
Brown, Nat F
Provias, John
Finlay, B Brett
Coombes, Brian K
Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain
title Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain
title_full Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain
title_fullStr Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain
title_full_unstemmed Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain
title_short Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain
title_sort oral infection of mice with salmonella enterica serovar typhimurium causes meningitis and infection of the brain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1925087/
https://www.ncbi.nlm.nih.gov/pubmed/17597539
http://dx.doi.org/10.1186/1471-2334-7-65
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AT proviasjohn oralinfectionofmicewithsalmonellaentericaserovartyphimuriumcausesmeningitisandinfectionofthebrain
AT finlaybbrett oralinfectionofmicewithsalmonellaentericaserovartyphimuriumcausesmeningitisandinfectionofthebrain
AT coombesbriank oralinfectionofmicewithsalmonellaentericaserovartyphimuriumcausesmeningitisandinfectionofthebrain

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