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Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis
Gene expression signatures consisting of tens to hundreds of genes have been found to be informative for different biological states. Recently, many computational methods have been proposed for biological interpretation of such signatures. However, there is a lack of methods for identifying cell sig...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1929148/ https://www.ncbi.nlm.nih.gov/pubmed/17498287 http://dx.doi.org/10.1186/gb-2007-8-5-r77 |
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author | Liu, Yingchun Ringnér, Markus |
author_facet | Liu, Yingchun Ringnér, Markus |
author_sort | Liu, Yingchun |
collection | PubMed |
description | Gene expression signatures consisting of tens to hundreds of genes have been found to be informative for different biological states. Recently, many computational methods have been proposed for biological interpretation of such signatures. However, there is a lack of methods for identifying cell signaling pathways whose deregulation results in an observed expression signature. We present a strategy for identifying such signaling pathways and evaluate the strategy using six human and mouse gene expression signatures. |
format | Text |
id | pubmed-1929148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-19291482007-07-21 Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis Liu, Yingchun Ringnér, Markus Genome Biol Method Gene expression signatures consisting of tens to hundreds of genes have been found to be informative for different biological states. Recently, many computational methods have been proposed for biological interpretation of such signatures. However, there is a lack of methods for identifying cell signaling pathways whose deregulation results in an observed expression signature. We present a strategy for identifying such signaling pathways and evaluate the strategy using six human and mouse gene expression signatures. BioMed Central 2007 2007-05-11 /pmc/articles/PMC1929148/ /pubmed/17498287 http://dx.doi.org/10.1186/gb-2007-8-5-r77 Text en Copyright © 2007 Liu and Ringnér; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Method Liu, Yingchun Ringnér, Markus Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis |
title | Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis |
title_full | Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis |
title_fullStr | Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis |
title_full_unstemmed | Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis |
title_short | Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis |
title_sort | revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis |
topic | Method |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1929148/ https://www.ncbi.nlm.nih.gov/pubmed/17498287 http://dx.doi.org/10.1186/gb-2007-8-5-r77 |
work_keys_str_mv | AT liuyingchun revealingsignalingpathwayderegulationbyusinggeneexpressionsignaturesandregulatorymotifanalysis AT ringnermarkus revealingsignalingpathwayderegulationbyusinggeneexpressionsignaturesandregulatorymotifanalysis |