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Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis

Gene expression signatures consisting of tens to hundreds of genes have been found to be informative for different biological states. Recently, many computational methods have been proposed for biological interpretation of such signatures. However, there is a lack of methods for identifying cell sig...

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Detalles Bibliográficos
Autores principales: Liu, Yingchun, Ringnér, Markus
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1929148/
https://www.ncbi.nlm.nih.gov/pubmed/17498287
http://dx.doi.org/10.1186/gb-2007-8-5-r77
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author Liu, Yingchun
Ringnér, Markus
author_facet Liu, Yingchun
Ringnér, Markus
author_sort Liu, Yingchun
collection PubMed
description Gene expression signatures consisting of tens to hundreds of genes have been found to be informative for different biological states. Recently, many computational methods have been proposed for biological interpretation of such signatures. However, there is a lack of methods for identifying cell signaling pathways whose deregulation results in an observed expression signature. We present a strategy for identifying such signaling pathways and evaluate the strategy using six human and mouse gene expression signatures.
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spelling pubmed-19291482007-07-21 Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis Liu, Yingchun Ringnér, Markus Genome Biol Method Gene expression signatures consisting of tens to hundreds of genes have been found to be informative for different biological states. Recently, many computational methods have been proposed for biological interpretation of such signatures. However, there is a lack of methods for identifying cell signaling pathways whose deregulation results in an observed expression signature. We present a strategy for identifying such signaling pathways and evaluate the strategy using six human and mouse gene expression signatures. BioMed Central 2007 2007-05-11 /pmc/articles/PMC1929148/ /pubmed/17498287 http://dx.doi.org/10.1186/gb-2007-8-5-r77 Text en Copyright © 2007 Liu and Ringnér; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Method
Liu, Yingchun
Ringnér, Markus
Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis
title Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis
title_full Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis
title_fullStr Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis
title_full_unstemmed Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis
title_short Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis
title_sort revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis
topic Method
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1929148/
https://www.ncbi.nlm.nih.gov/pubmed/17498287
http://dx.doi.org/10.1186/gb-2007-8-5-r77
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