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Notch-induced T cell development requires phosphoinositide-dependent kinase 1

Phosphoinositide-dependent kinase l (PDK1) phosphorylates and activates multiple AGC serine kinases, including protein kinase B (PKB), p70Ribosomal S6 kinase (S6K) and p90Ribosomal S6 kinase (RSK). PDK1 is required for thymocyte differentiation and proliferation, and herein, we explore the molecular...

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Detalles Bibliográficos
Autores principales:	Kelly, April P, Finlay, David K, Hinton, Heather J, Clarke, Rosie G, Fiorini, Emma, Radtke, Freddy, Cantrell, Doreen A
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2007
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933393/ https://www.ncbi.nlm.nih.gov/pubmed/17599070 http://dx.doi.org/10.1038/sj.emboj.7601761

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