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Regulated Degradation of the HIV-1 Vpu Protein through a βTrCP-Independent Pathway Limits the Release of Viral Particles

Viral protein U (Vpu) of HIV-1 has two known functions in replication of the virus: degradation of its cellular receptor CD4 and enhancement of viral particle release. Vpu binds CD4 and simultaneously recruits the βTrCP subunit of the SCF(βTrCP) ubiquitin ligase complex through its constitutively ph...

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Detalles Bibliográficos
Autores principales:	Estrabaud, Emilie, Le Rouzic, Erwann, Lopez-Vergès, Sandra, Morel, Marina, Belaïdouni, Nadia, Benarous, Richard, Transy, Catherine, Berlioz-Torrent, Clarisse, Margottin-Goguet, Florence
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933454/ https://www.ncbi.nlm.nih.gov/pubmed/17676996 http://dx.doi.org/10.1371/journal.ppat.0030104

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