Quantitative Analysis of Cell Nucleus Organisation

There are almost 1,300 entries for higher eukaryotes in the Nuclear Protein Database. The proteins' subcellular distribution patterns within interphase nuclei can be complex, ranging from diffuse to punctate or microspeckled, yet they all work together in a coordinated and controlled manner wit...

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Detalles Bibliográficos
Autores principales: Shiels, Carol, Adams, Niall M, Islam, Suhail A, Stephens, David A, Freemont, Paul S
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933473/
https://www.ncbi.nlm.nih.gov/pubmed/17676980
http://dx.doi.org/10.1371/journal.pcbi.0030138
Descripción
Sumario:There are almost 1,300 entries for higher eukaryotes in the Nuclear Protein Database. The proteins' subcellular distribution patterns within interphase nuclei can be complex, ranging from diffuse to punctate or microspeckled, yet they all work together in a coordinated and controlled manner within the three-dimensional confines of the nuclear volume. In this review we describe recent advances in the use of quantitative methods to understand nuclear spatial organisation and discuss some of the practical applications resulting from this work.

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