Quantitative Analysis of Cell Nucleus Organisation

There are almost 1,300 entries for higher eukaryotes in the Nuclear Protein Database. The proteins' subcellular distribution patterns within interphase nuclei can be complex, ranging from diffuse to punctate or microspeckled, yet they all work together in a coordinated and controlled manner wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Shiels, Carol, Adams, Niall M, Islam, Suhail A, Stephens, David A, Freemont, Paul S
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933473/
https://www.ncbi.nlm.nih.gov/pubmed/17676980
http://dx.doi.org/10.1371/journal.pcbi.0030138
_version_ 1782134330870464512
author Shiels, Carol
Adams, Niall M
Islam, Suhail A
Stephens, David A
Freemont, Paul S
author_facet Shiels, Carol
Adams, Niall M
Islam, Suhail A
Stephens, David A
Freemont, Paul S
author_sort Shiels, Carol
collection PubMed
description There are almost 1,300 entries for higher eukaryotes in the Nuclear Protein Database. The proteins' subcellular distribution patterns within interphase nuclei can be complex, ranging from diffuse to punctate or microspeckled, yet they all work together in a coordinated and controlled manner within the three-dimensional confines of the nuclear volume. In this review we describe recent advances in the use of quantitative methods to understand nuclear spatial organisation and discuss some of the practical applications resulting from this work.
format Text
id pubmed-1933473
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-19334732007-07-26 Quantitative Analysis of Cell Nucleus Organisation Shiels, Carol Adams, Niall M Islam, Suhail A Stephens, David A Freemont, Paul S PLoS Comput Biol Review There are almost 1,300 entries for higher eukaryotes in the Nuclear Protein Database. The proteins' subcellular distribution patterns within interphase nuclei can be complex, ranging from diffuse to punctate or microspeckled, yet they all work together in a coordinated and controlled manner within the three-dimensional confines of the nuclear volume. In this review we describe recent advances in the use of quantitative methods to understand nuclear spatial organisation and discuss some of the practical applications resulting from this work. Public Library of Science 2007-07 2007-07-27 /pmc/articles/PMC1933473/ /pubmed/17676980 http://dx.doi.org/10.1371/journal.pcbi.0030138 Text en © 2007 Shiels et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Review
Shiels, Carol
Adams, Niall M
Islam, Suhail A
Stephens, David A
Freemont, Paul S
Quantitative Analysis of Cell Nucleus Organisation
title Quantitative Analysis of Cell Nucleus Organisation
title_full Quantitative Analysis of Cell Nucleus Organisation
title_fullStr Quantitative Analysis of Cell Nucleus Organisation
title_full_unstemmed Quantitative Analysis of Cell Nucleus Organisation
title_short Quantitative Analysis of Cell Nucleus Organisation
title_sort quantitative analysis of cell nucleus organisation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933473/
https://www.ncbi.nlm.nih.gov/pubmed/17676980
http://dx.doi.org/10.1371/journal.pcbi.0030138
work_keys_str_mv AT shielscarol quantitativeanalysisofcellnucleusorganisation
AT adamsniallm quantitativeanalysisofcellnucleusorganisation
AT islamsuhaila quantitativeanalysisofcellnucleusorganisation
AT stephensdavida quantitativeanalysisofcellnucleusorganisation
AT freemontpauls quantitativeanalysisofcellnucleusorganisation

Ejemplares similares