Cis-Cotranscription of Two Beta Globin Genes during Chicken Primitive Hematopoiesis

Chicken beta globin locus contains four genes, two of which, rho and epsilon, are expressed from the earliest stage of primitive hematopoiesis. Here we show that the transcription of these two genes in the nucleus engages in “on/off” phases. During each “on” phase, cotranscription of rho and epsilon...

Descripción completa

Detalles Bibliográficos
Autores principales: Nagai, Hiroki, Sheng, Guojun
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934934/
https://www.ncbi.nlm.nih.gov/pubmed/17684550
http://dx.doi.org/10.1371/journal.pone.0000703
_version_ 1782134357505343488
author Nagai, Hiroki
Sheng, Guojun
author_facet Nagai, Hiroki
Sheng, Guojun
author_sort Nagai, Hiroki
collection PubMed
description Chicken beta globin locus contains four genes, two of which, rho and epsilon, are expressed from the earliest stage of primitive hematopoiesis. Here we show that the transcription of these two genes in the nucleus engages in “on/off” phases. During each “on” phase, cotranscription of rho and epsilon in cis is favored. We propose that these two chicken beta globin genes are transcribed not by competing for a transcription initiation complex, but in a cooperative way.
format Text
id pubmed-1934934
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-19349342007-08-08 Cis-Cotranscription of Two Beta Globin Genes during Chicken Primitive Hematopoiesis Nagai, Hiroki Sheng, Guojun PLoS One Research Article Chicken beta globin locus contains four genes, two of which, rho and epsilon, are expressed from the earliest stage of primitive hematopoiesis. Here we show that the transcription of these two genes in the nucleus engages in “on/off” phases. During each “on” phase, cotranscription of rho and epsilon in cis is favored. We propose that these two chicken beta globin genes are transcribed not by competing for a transcription initiation complex, but in a cooperative way. Public Library of Science 2007-08-08 /pmc/articles/PMC1934934/ /pubmed/17684550 http://dx.doi.org/10.1371/journal.pone.0000703 Text en Nagai, Sheng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Nagai, Hiroki
Sheng, Guojun
Cis-Cotranscription of Two Beta Globin Genes during Chicken Primitive Hematopoiesis
title Cis-Cotranscription of Two Beta Globin Genes during Chicken Primitive Hematopoiesis
title_full Cis-Cotranscription of Two Beta Globin Genes during Chicken Primitive Hematopoiesis
title_fullStr Cis-Cotranscription of Two Beta Globin Genes during Chicken Primitive Hematopoiesis
title_full_unstemmed Cis-Cotranscription of Two Beta Globin Genes during Chicken Primitive Hematopoiesis
title_short Cis-Cotranscription of Two Beta Globin Genes during Chicken Primitive Hematopoiesis
title_sort cis-cotranscription of two beta globin genes during chicken primitive hematopoiesis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934934/
https://www.ncbi.nlm.nih.gov/pubmed/17684550
http://dx.doi.org/10.1371/journal.pone.0000703
work_keys_str_mv AT nagaihiroki ciscotranscriptionoftwobetaglobingenesduringchickenprimitivehematopoiesis
AT shengguojun ciscotranscriptionoftwobetaglobingenesduringchickenprimitivehematopoiesis

Ejemplares similares