Efficient splicing correction by PNA conjugation to an R(6)-Penetratin delivery peptide

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Sequence-specific interference with the nuclear pre-mRNA splicing machinery has received increased attention as an analytical tool and for development of therapeutics. It requires sequence-specific and high affinity binding of RNaseH-incompetent DNA mimics to pre-mRNA. Peptide nucleic acids (PNA) or...

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Detalles Bibliográficos
Autores principales: Abes, Saïd, Turner, John J., Ivanova, Gabriela D., Owen, David, Williams, Donna, Arzumanov, Andrey, Clair, Philippe, Gait, Michael J., Lebleu, Bernard
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934994/
https://www.ncbi.nlm.nih.gov/pubmed/17584792
http://dx.doi.org/10.1093/nar/gkm418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934994/
https://www.ncbi.nlm.nih.gov/pubmed/17584792
http://dx.doi.org/10.1093/nar/gkm418

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