Cargando…

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

By enzymatically hydrolyzing the terminal phosphodiester bond at the 3′-ends of DNA breaks, tyrosyl-DNA phosphodiesterase (Tdp1) repairs topoisomerase-DNA covalent complexes and processes the DNA ends for DNA repair. To identify novel Tdp1 inhibitors, we developed a high-throughput assay that uses e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Antony, Smitha, Marchand, Christophe, Stephen, Andrew G., Thibaut, Laurent, Agama, Keli K., Fisher, Robert J., Pommier, Yves
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2007
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1935015/ https://www.ncbi.nlm.nih.gov/pubmed/17576665 http://dx.doi.org/10.1093/nar/gkm463

Ejemplares similares

The DNA binding and 3′-end preferential activity of human tyrosyl-DNA phosphodiesterase
por: Dexheimer, Thomas S., et al.
Publicado: (2010)

The Human Tyrosyl-DNA Phosphodiesterase 1 (hTdp1) Inhibitor NSC120686 as an Exploratory Tool to Investigate Plant Tdp1 Genes
por: Macovei, Anca, et al.
Publicado: (2018)

TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs
por: Huang, Shar-yin N., et al.
Publicado: (2013)

Reversal of DNA damage induced Topoisomerase 2 DNA–protein crosslinks by Tdp2
por: Schellenberg, Matthew J., et al.
Publicado: (2016)

Design, Synthesis, and Biological Evaluation of O-2-Modified Indenoisoquinolines as Dual Topoisomerase I–Tyrosyl-DNA Phosphodiesterase I Inhibitors
por: Lv, Peng-Cheng, et al.
Publicado: (2014)

Selectivity for strand-transfer over 3′-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme–DNA interactions in the active site
por: Métifiot, Mathieu, et al.
Publicado: (2016)

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors
por: Walker, Sarah, et al.
Publicado: (2014)

Functional replacement of the endogenous tyrosyl-tRNA synthetase–tRNA(Tyr) pair by the archaeal tyrosine pair in Escherichia coli for genetic code expansion
por: Iraha, Fumie, et al.
Publicado: (2010)

The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme
por: Gladkova, Elizaveta D., et al.
Publicado: (2020)

Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification
por: Zhao, Xue Zhi, et al.
Publicado: (2023)

Human 2′-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover
por: Poulsen, Jesper Buchhave, et al.
Publicado: (2011)

Unique subunit packing in mycobacterial nanoRNase leads to alternate substrate recognitions in DHH phosphodiesterases
por: Srivastav, Rajpal, et al.
Publicado: (2014)

Structural basis for the evolution of cyclic phosphodiesterase activity in the U6 snRNA exoribonuclease Usb1
por: Nomura, Yuichiro, et al.
Publicado: (2020)

Characterization of the 2′,3′ cyclic phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase-phosphatase and bacteriophage λ phosphatase
por: Keppetipola, Niroshika, et al.
Publicado: (2007)

Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase
por: Ndongwe, Tanyaradzwa P., et al.
Publicado: (2012)

The sequential 2′,3′-cyclic phosphodiesterase and 3′-phosphate/5′-OH ligation steps of the RtcB RNA splicing pathway are GTP-dependent
por: Chakravarty, Anupam K., et al.
Publicado: (2012)

Interactions between branched DNAs and peptide inhibitors of DNA repair
por: Kepple, Kevin V., et al.
Publicado: (2008)

Derivatives of Bst-like Gss-polymerase with improved processivity and inhibitor tolerance
por: Oscorbin, Igor P., et al.
Publicado: (2017)

Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors
por: Kaushik-Basu, Neerja, et al.
Publicado: (2008)

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase
por: Redon, Sophie, et al.
Publicado: (2010)

Atomic structures of the RNA end-healing 5′-OH kinase and 2′,3′-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor
por: Banerjee, Ankan, et al.
Publicado: (2019)

Discovery of potent and versatile CRISPR–Cas9 inhibitors engineered for chemically controllable genome editing
por: Song, Guoxu, et al.
Publicado: (2022)

Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays
por: Mukherjee, Sourav, et al.
Publicado: (2012)

Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria
por: Zhang, Hongliang, et al.
Publicado: (2014)

Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy
por: Khomenko, Tatyana M., et al.
Publicado: (2019)

Design, Synthesis, and Molecular Docking Study of New Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors Combining Resin Acids and Adamantane Moieties
por: Kovaleva, Kseniya, et al.
Publicado: (2021)

2′-Deoxyriboguanylurea, the primary breakdown product of 5-aza-2′-deoxyribocytidine, is a mutagen, an epimutagen, an inhibitor of DNA methyltransferases and an inducer of 5-azacytidine-type fragile sites
por: Lamparska, Katarzyna, et al.
Publicado: (2012)

Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors
por: Schneider, Anna, et al.
Publicado: (2016)

Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2′,5′-oligoadenylate synthetase from prostate cancer cells
por: Molinaro, Ross J., et al.
Publicado: (2006)

topIb, a phylogenetic hallmark gene of Thaumarchaeota encodes a functional eukaryote-like topoisomerase IB
por: Dahmane, Narimane, et al.
Publicado: (2016)

Deficiency in 3′-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)
por: Zhou, Tong, et al.
Publicado: (2005)

Mechanism of 5′ Topoisomerase II DNA adduct repair by mammalian Tyrosyl DNA phosphodiesterase 2 (Tdp2)
por: Schellenberg, Matthew J., et al.
Publicado: (2012)

The Tyrosyl-DNA Phosphodiesterase 1β (Tdp1β) Gene Discloses an Early Response to Abiotic Stresses
por: Sabatini, Maria Elisa, et al.
Publicado: (2017)

Plant TDP1 (Tyrosyl-DNA Phosphodiesterase 1): A Phylogenetic Perspective and Gene Expression Data Mining
por: Mutti, Giacomo, et al.
Publicado: (2020)

Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1
por: Zhao, Xue Zhi, et al.
Publicado: (2022)

Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I
por: Sobek, Stefan, et al.
Publicado: (2013)

RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals
por: Ahmad, Muzammil, et al.
Publicado: (2016)

RNase R is associated in a functional complex with the RhpA DEAD-box RNA helicase in Helicobacter pylori
por: Tejada-Arranz, Alejandro, et al.
Publicado: (2021)

tRNA 2′-O-methylation by a duo of TRM7/FTSJ1 proteins modulates small RNA silencing in Drosophila
por: Angelova, Margarita T, et al.
Publicado: (2020)

Repair of topoisomerase 1–induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding
por: Shimizu, Naoto, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_oos6b70oj2chc4i8u2qbtshiom