Comparative genomics of archaea: how much have we learned in six years, and what's next?

Archaea comprise one of the three distinct domains of life (with bacteria and eukaryotes). With 16 complete archaeal genomes sequenced to date, comparative genomics has revealed a conserved core of 313 genes that are represented in all sequenced archaeal genomes, plus a variable 'shell' th...

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Detalles Bibliográficos
Autores principales: Makarova, Kira S, Koonin, Eugene V
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC193635/
https://www.ncbi.nlm.nih.gov/pubmed/12914651
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author Makarova, Kira S
Koonin, Eugene V
author_facet Makarova, Kira S
Koonin, Eugene V
author_sort Makarova, Kira S
collection PubMed
description Archaea comprise one of the three distinct domains of life (with bacteria and eukaryotes). With 16 complete archaeal genomes sequenced to date, comparative genomics has revealed a conserved core of 313 genes that are represented in all sequenced archaeal genomes, plus a variable 'shell' that is prone to lineage-specific gene loss and horizontal gene exchange. The majority of archaeal genes have not been experimentally characterized, but novel functional pathways have been predicted.
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spelling pubmed-1936352003-09-15 Comparative genomics of archaea: how much have we learned in six years, and what's next? Makarova, Kira S Koonin, Eugene V Genome Biol Opinion Archaea comprise one of the three distinct domains of life (with bacteria and eukaryotes). With 16 complete archaeal genomes sequenced to date, comparative genomics has revealed a conserved core of 313 genes that are represented in all sequenced archaeal genomes, plus a variable 'shell' that is prone to lineage-specific gene loss and horizontal gene exchange. The majority of archaeal genes have not been experimentally characterized, but novel functional pathways have been predicted. BioMed Central 2003 2003-07-16 /pmc/articles/PMC193635/ /pubmed/12914651 Text en Copyright © 2003 BioMed Central Ltd
spellingShingle Opinion
Makarova, Kira S
Koonin, Eugene V
Comparative genomics of archaea: how much have we learned in six years, and what's next?
title Comparative genomics of archaea: how much have we learned in six years, and what's next?
title_full Comparative genomics of archaea: how much have we learned in six years, and what's next?
title_fullStr Comparative genomics of archaea: how much have we learned in six years, and what's next?
title_full_unstemmed Comparative genomics of archaea: how much have we learned in six years, and what's next?
title_short Comparative genomics of archaea: how much have we learned in six years, and what's next?
title_sort comparative genomics of archaea: how much have we learned in six years, and what's next?
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC193635/
https://www.ncbi.nlm.nih.gov/pubmed/12914651
work_keys_str_mv AT makarovakiras comparativegenomicsofarchaeahowmuchhavewelearnedinsixyearsandwhatsnext
AT koonineugenev comparativegenomicsofarchaeahowmuchhavewelearnedinsixyearsandwhatsnext

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