THoR: a tool for domain discovery and curation of multiple alignments

We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-b...

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Detalles Bibliográficos
Autores principales: Dickens, Nicholas J, Ponting, Chris P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC193644/
https://www.ncbi.nlm.nih.gov/pubmed/12914660
Descripción
Sumario:We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-browser, with simple links and cross-references to relevant information, to assist the assessment of biological significance. THoR has been benchmarked for accuracy using the SMART and pufferfish genome databases.

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