THoR: a tool for domain discovery and curation of multiple alignments

We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-b...

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Detalles Bibliográficos
Autores principales: Dickens, Nicholas J, Ponting, Chris P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC193644/
https://www.ncbi.nlm.nih.gov/pubmed/12914660
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author Dickens, Nicholas J
Ponting, Chris P
author_facet Dickens, Nicholas J
Ponting, Chris P
author_sort Dickens, Nicholas J
collection PubMed
description We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-browser, with simple links and cross-references to relevant information, to assist the assessment of biological significance. THoR has been benchmarked for accuracy using the SMART and pufferfish genome databases.
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spelling pubmed-1936442003-09-15 THoR: a tool for domain discovery and curation of multiple alignments Dickens, Nicholas J Ponting, Chris P Genome Biol Software We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-browser, with simple links and cross-references to relevant information, to assist the assessment of biological significance. THoR has been benchmarked for accuracy using the SMART and pufferfish genome databases. BioMed Central 2003 2003-07-23 /pmc/articles/PMC193644/ /pubmed/12914660 Text en Copyright © 2003 Dickens and Ponting; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Software
Dickens, Nicholas J
Ponting, Chris P
THoR: a tool for domain discovery and curation of multiple alignments
title THoR: a tool for domain discovery and curation of multiple alignments
title_full THoR: a tool for domain discovery and curation of multiple alignments
title_fullStr THoR: a tool for domain discovery and curation of multiple alignments
title_full_unstemmed THoR: a tool for domain discovery and curation of multiple alignments
title_short THoR: a tool for domain discovery and curation of multiple alignments
title_sort thor: a tool for domain discovery and curation of multiple alignments
topic Software
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC193644/
https://www.ncbi.nlm.nih.gov/pubmed/12914660
work_keys_str_mv AT dickensnicholasj thoratoolfordomaindiscoveryandcurationofmultiplealignments
AT pontingchrisp thoratoolfordomaindiscoveryandcurationofmultiplealignments

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