CpG content affects gene silencing in mice: evidence from novel transgenes

BACKGROUND: Transgenes are often engineered using regulatory elements from distantly related genomes. Although correct expression patterns are frequently achieved even in transgenic mice, inappropriate expression, especially with promoters of widely expressed genes, has been reported. DNA methylatio...

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Detalles Bibliográficos
Autores principales: Chevalier-Mariette, Christine, Henry, Isabelle, Montfort, Lucile, Capgras, Suzanne, Forlani, Sylvie, Muschler, John, Nicolas, Jean-François
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC193653/
https://www.ncbi.nlm.nih.gov/pubmed/12952532

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