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RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?

BACKGROUND: Radiofrequency ablation (RFA) of tumors by means of internally cooled electrodes (ICE) combined with interstitial infusion of saline may improve clinical results. To date, infusion has been conducted through outlets placed on the surface of the cooled electrode. However, the effect of in...

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Autores principales: Burdío, Fernando, Berjano, Enrique J, Navarro, Ana, Burdío, José M, Güemes, Antonio, Grande, Luis, Sousa, Ramón, Subiró, Jorge, Gonzalez, Ana, Cruz, Ignacio, Castiella, Tomás, Tejero, Eloy, Lozano, Ricardo, de Gregorio, Miguel A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936989/
https://www.ncbi.nlm.nih.gov/pubmed/17634117
http://dx.doi.org/10.1186/1475-925X-6-30
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author Burdío, Fernando
Berjano, Enrique J
Navarro, Ana
Burdío, José M
Güemes, Antonio
Grande, Luis
Sousa, Ramón
Subiró, Jorge
Gonzalez, Ana
Cruz, Ignacio
Castiella, Tomás
Tejero, Eloy
Lozano, Ricardo
de Gregorio, Miguel A
author_facet Burdío, Fernando
Berjano, Enrique J
Navarro, Ana
Burdío, José M
Güemes, Antonio
Grande, Luis
Sousa, Ramón
Subiró, Jorge
Gonzalez, Ana
Cruz, Ignacio
Castiella, Tomás
Tejero, Eloy
Lozano, Ricardo
de Gregorio, Miguel A
author_sort Burdío, Fernando
collection PubMed
description BACKGROUND: Radiofrequency ablation (RFA) of tumors by means of internally cooled electrodes (ICE) combined with interstitial infusion of saline may improve clinical results. To date, infusion has been conducted through outlets placed on the surface of the cooled electrode. However, the effect of infusion at a distance from the electrode surface is unknown. Our aim was to assess the effect of perfusion distance (PD) on the coagulation geometry and deposited power during RFA using ICE. METHODS: Experiments were performed on excised bovine livers. Perfusion distance (PD) was defined as the shortest distance between the infusion outlet and the surface of the ICE. We considered three values of PD: 0, 2 and 4 mm. Two sets of experiments were considered: 1) 15 ablations of 10 minutes (n ≥ 4 for each PD), in order to evaluate the effect of PD on volume and diameters of coagulation; and 2) 20 additional ablations of 20 minutes. The effect of PD on deposited power and relative frequency of uncontrolled impedance rises (roll-off) was evaluated using the results from the two sets of experiments (n ≥ 7 for each PD). Comparisons between PD were performed by analysis of variance or Kruskal-Wallis test. Additionally, non-linear regression models were performed to elucidate the best PD in terms of coagulation volume and diameter, and the occurrence of uncontrolled impedance rises. RESULTS: The best-fit least square functions were always obtained with quadratic curves where volume and diameters of coagulation were maximum for a PD of 2 mm. A thirty per cent increase in volume coagulation was observed for this PD value compared to other values (P < 0.05). Likewise, the short coagulation diameter was nearly twenty five per cent larger for a 2 mm PD than for 0 mm. Regarding deposited power, the best-fit least square function was obtained by a quadratic curve with a 2 mm PD peak. This matched well with the higher relative frequency of uncontrolled impedance rises for PD of 0 and 4 mm. CONCLUSION: Saline perfusion at around 2 mm from the electrode surface while using an ICE in RFA improves deposition of energy and enlarges coagulation volume.
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spelling pubmed-19369892007-08-02 RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion? Burdío, Fernando Berjano, Enrique J Navarro, Ana Burdío, José M Güemes, Antonio Grande, Luis Sousa, Ramón Subiró, Jorge Gonzalez, Ana Cruz, Ignacio Castiella, Tomás Tejero, Eloy Lozano, Ricardo de Gregorio, Miguel A Biomed Eng Online Research BACKGROUND: Radiofrequency ablation (RFA) of tumors by means of internally cooled electrodes (ICE) combined with interstitial infusion of saline may improve clinical results. To date, infusion has been conducted through outlets placed on the surface of the cooled electrode. However, the effect of infusion at a distance from the electrode surface is unknown. Our aim was to assess the effect of perfusion distance (PD) on the coagulation geometry and deposited power during RFA using ICE. METHODS: Experiments were performed on excised bovine livers. Perfusion distance (PD) was defined as the shortest distance between the infusion outlet and the surface of the ICE. We considered three values of PD: 0, 2 and 4 mm. Two sets of experiments were considered: 1) 15 ablations of 10 minutes (n ≥ 4 for each PD), in order to evaluate the effect of PD on volume and diameters of coagulation; and 2) 20 additional ablations of 20 minutes. The effect of PD on deposited power and relative frequency of uncontrolled impedance rises (roll-off) was evaluated using the results from the two sets of experiments (n ≥ 7 for each PD). Comparisons between PD were performed by analysis of variance or Kruskal-Wallis test. Additionally, non-linear regression models were performed to elucidate the best PD in terms of coagulation volume and diameter, and the occurrence of uncontrolled impedance rises. RESULTS: The best-fit least square functions were always obtained with quadratic curves where volume and diameters of coagulation were maximum for a PD of 2 mm. A thirty per cent increase in volume coagulation was observed for this PD value compared to other values (P < 0.05). Likewise, the short coagulation diameter was nearly twenty five per cent larger for a 2 mm PD than for 0 mm. Regarding deposited power, the best-fit least square function was obtained by a quadratic curve with a 2 mm PD peak. This matched well with the higher relative frequency of uncontrolled impedance rises for PD of 0 and 4 mm. CONCLUSION: Saline perfusion at around 2 mm from the electrode surface while using an ICE in RFA improves deposition of energy and enlarges coagulation volume. BioMed Central 2007-07-16 /pmc/articles/PMC1936989/ /pubmed/17634117 http://dx.doi.org/10.1186/1475-925X-6-30 Text en Copyright © 2007 Burdío et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Burdío, Fernando
Berjano, Enrique J
Navarro, Ana
Burdío, José M
Güemes, Antonio
Grande, Luis
Sousa, Ramón
Subiró, Jorge
Gonzalez, Ana
Cruz, Ignacio
Castiella, Tomás
Tejero, Eloy
Lozano, Ricardo
de Gregorio, Miguel A
RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?
title RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?
title_full RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?
title_fullStr RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?
title_full_unstemmed RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?
title_short RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?
title_sort rf tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936989/
https://www.ncbi.nlm.nih.gov/pubmed/17634117
http://dx.doi.org/10.1186/1475-925X-6-30
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