PERIOD–TIMELESS Interval Timer May Require an Additional Feedback Loop

In this study we present a detailed, mechanism-based mathematical framework of Drosophila circadian rhythms. This framework facilitates a more systematic approach to understanding circadian rhythms using a comprehensive representation of the network underlying this phenomenon. The possible mechanism...

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Detalles Bibliográficos
Autores principales: Kuczenski, Robert S, Hong, Kevin C, García-Ojalvo, Jordi, Lee, Kelvin H
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1937016/
https://www.ncbi.nlm.nih.gov/pubmed/17676950
http://dx.doi.org/10.1371/journal.pcbi.0030154
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author Kuczenski, Robert S
Hong, Kevin C
García-Ojalvo, Jordi
Lee, Kelvin H
author_facet Kuczenski, Robert S
Hong, Kevin C
García-Ojalvo, Jordi
Lee, Kelvin H
author_sort Kuczenski, Robert S
collection PubMed
description In this study we present a detailed, mechanism-based mathematical framework of Drosophila circadian rhythms. This framework facilitates a more systematic approach to understanding circadian rhythms using a comprehensive representation of the network underlying this phenomenon. The possible mechanisms underlying the cytoplasmic “interval timer” created by PERIOD–TIMELESS association are investigated, suggesting a novel positive feedback regulatory structure. Incorporation of this additional feedback into a full circadian model produced results that are consistent with previous experimental observations of wild-type protein profiles and numerous mutant phenotypes.
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spelling pubmed-19370162007-09-07 PERIOD–TIMELESS Interval Timer May Require an Additional Feedback Loop Kuczenski, Robert S Hong, Kevin C García-Ojalvo, Jordi Lee, Kelvin H PLoS Comput Biol Research Article In this study we present a detailed, mechanism-based mathematical framework of Drosophila circadian rhythms. This framework facilitates a more systematic approach to understanding circadian rhythms using a comprehensive representation of the network underlying this phenomenon. The possible mechanisms underlying the cytoplasmic “interval timer” created by PERIOD–TIMELESS association are investigated, suggesting a novel positive feedback regulatory structure. Incorporation of this additional feedback into a full circadian model produced results that are consistent with previous experimental observations of wild-type protein profiles and numerous mutant phenotypes. Public Library of Science 2007-08 2007-08-03 /pmc/articles/PMC1937016/ /pubmed/17676950 http://dx.doi.org/10.1371/journal.pcbi.0030154 Text en © 2007 Kuczenski et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kuczenski, Robert S
Hong, Kevin C
García-Ojalvo, Jordi
Lee, Kelvin H
PERIOD–TIMELESS Interval Timer May Require an Additional Feedback Loop
title PERIOD–TIMELESS Interval Timer May Require an Additional Feedback Loop
title_full PERIOD–TIMELESS Interval Timer May Require an Additional Feedback Loop
title_fullStr PERIOD–TIMELESS Interval Timer May Require an Additional Feedback Loop
title_full_unstemmed PERIOD–TIMELESS Interval Timer May Require an Additional Feedback Loop
title_short PERIOD–TIMELESS Interval Timer May Require an Additional Feedback Loop
title_sort period–timeless interval timer may require an additional feedback loop
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1937016/
https://www.ncbi.nlm.nih.gov/pubmed/17676950
http://dx.doi.org/10.1371/journal.pcbi.0030154
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AT garciaojalvojordi periodtimelessintervaltimermayrequireanadditionalfeedbackloop
AT leekelvinh periodtimelessintervaltimermayrequireanadditionalfeedbackloop

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