Cargando…

Image-Based Modeling Reveals Dynamic Redistribution of DNA Damage into Nuclear Sub-Domains

Several proteins involved in the response to DNA double strand breaks (DSB) form microscopically visible nuclear domains, or foci, after exposure to ionizing radiation. Radiation-induced foci (RIF) are believed to be located where DNA damage occurs. To test this assumption, we analyzed the spatial d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Costes, Sylvain V, Ponomarev, Artem, Chen, James L, Nguyen, David, Cucinotta, Francis A, Barcellos-Hoff, Mary Helen
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1937017/ https://www.ncbi.nlm.nih.gov/pubmed/17676951 http://dx.doi.org/10.1371/journal.pcbi.0030155

Ejemplares similares

Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies
por: Mukhopadhyay, Rituparna, et al.
Publicado: (2010)

Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains
Publicado: (1995)

BUB1-bling over with Possibilities
por: Barcellos-Hoff, Mary Helen
Publicado: (2015)

Cell survival and redistribution after transplantation into damaged myocardium
por: Zhang, Hao, et al.
Publicado: (2010)

Misrepair in Context: TGFβ Regulation of DNA Repair
por: Liu, Qi, et al.
Publicado: (2019)

Systems biology perspectives on the carcinogenic potential of radiation
por: Barcellos-Hoff, Mary Helen, et al.
Publicado: (2014)

Cleavage and Sub-Cellular Redistribution of Nuclear Pore Protein 98 by Coxsackievirus B3 Protease 2A Impairs Cardioprotection
por: Hanson, Paul J., et al.
Publicado: (2019)

In Situ Detection of Complex DNA Damage Using Microscopy: A Rough Road Ahead
por: Nikitaki, Zacharenia, et al.
Publicado: (2020)

Quantitative analysis of condensation/decondensation status of pDNA in the nuclear sub-domains by QD-FRET
por: Shaheen, Sharif M., et al.
Publicado: (2011)

New highlights on stroma–epithelial interactions in breast cancer
por: Barcellos-Hoff, Mary Helen, et al.
Publicado: (2005)

Editorial: Cell Signaling Mediating Critical Radiation Responses
por: Herskind, Carsten, et al.
Publicado: (2021)

The prionlike domain of FUS is multiphosphorylated following DNA damage without altering nuclear localization
por: Rhoads, Shannon N., et al.
Publicado: (2018)

Changes in intra-nuclear mechanics in response to DNA damaging agents revealed by time-domain Brillouin micro-spectroscopy
por: Liu, Liwang, et al.
Publicado: (2022)

Redistribution of nuclear ribonucleoprotein antigens during herpes simplex virus infection
Publicado: (1987)

Transforming growth factor-β in breast cancer: too much, too late
por: Barcellos-Hoff, Mary Helen, et al.
Publicado: (2009)

Transforming growth factor-β and breast cancer: Mammary gland development
por: Barcellos-Hoff, Mary Helen, et al.
Publicado: (2000)

HZE Radiation Non-Targeted Effects on the Microenvironment That Mediate Mammary Carcinogenesis
por: Barcellos-Hoff, Mary Helen, et al.
Publicado: (2016)

Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment
Publicado: (1995)

Syncytial nuclear aggregates in normal placenta show increased nuclear condensation, but apoptosis and cytoskeletal redistribution are uncommon
por: Coleman, S.J., et al.
Publicado: (2013)

Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis
por: Gómez-Moutón, Concepción, et al.
Publicado: (2004)

Intersection of Small RNA Pathways in Arabidopsis thaliana Sub-Nuclear Domains
por: Pontes, Olga, et al.
Publicado: (2013)

The response to DNA damage in heterochromatin domains
por: Fortuny, Anna, et al.
Publicado: (2018)

Characterizing the DNA Damage Response by Cell Tracking Algorithms and Cell Features Classification Using High-Content Time-Lapse Analysis
por: Georgescu, Walter, et al.
Publicado: (2015)

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair
por: Guard, Steven E., et al.
Publicado: (2019)

The spring-loaded genome: Nucleosome redistributions are widespread, transient, and DNA-directed
por: Sexton, Brittany S., et al.
Publicado: (2014)

Protein Sub-Nuclear Localization Prediction Using SVM and Pfam Domain Information
por: Kumar, Ravindra, et al.
Publicado: (2014)

Regulation of nuclear DNA damage response by mitochondrial morphofunctional pathway
por: Oanh, Nguyen Thi Kim, et al.
Publicado: (2022)

DNA Damage Baseline Predicts Resilience to Space Radiation and Radiotherapy
por: Pariset, Eloise, et al.
Publicado: (2020)

DNA damage induces nuclear translocation of parkin
por: Kao, Shyan-Yuan
Publicado: (2009)

Regulation of Nuclear Mechanics and the Impact on DNA Damage
por: dos Santos, Ália, et al.
Publicado: (2021)

PROTEINS IN NUCLEOCYTOPLASMIC INTERACTIONS : III. Redistributions of Nuclear Proteins During and Following Mitosis in Amoeba proteus
por: Prescott, David, et al.
Publicado: (1968)

Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein
por: Weins, Astrid, et al.
Publicado: (2001)

Loss of ISWI Function in Drosophila Nuclear Bodies Drives Cytoplasmic Redistribution of Drosophila TDP-43
por: Lo Piccolo, Luca, et al.
Publicado: (2018)

Imaging the Response to DNA Damage in Heterochromatin Domains
por: Chansard, Audrey, et al.
Publicado: (2022)

RSF-1 siRNA Enhances Tumor Radiosensitivity in Cervical Cancer via Enhanced DNA Damage, Cell Cycle Redistribution, and Promotion of Apoptosis
por: Tian, Jing, et al.
Publicado: (2020)

Nuclear Q/sub beta /-values for fission products A comparison with mass formula predictions
por: Aleklett, K, et al.
Publicado: (1981)

Conference on Freely-redistributable Software
Publicado: (1996)

Energy storage and redistribution in molecules
por: Hinze, Juergen
Publicado: (1983)

Inequality aversion and voting on redistribution()
por: Höchtl, Wolfgang, et al.
Publicado: (2012)

Cognitive Ability and the Demand for Redistribution
por: Mollerstrom, Johanna, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_8nuc8cbesm24b889s8dbe977nu