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Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status

BACKGROUND: It has been observed that ras-transformed cell lines in culture have a higher phosphatidylcholine (PC) biosynthesis rate as well as higher PC-degradation rate (increased PC-turnover) than normal cells. In correspondence to these findings, the concentrations of the PC-degradation product...

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Autores principales: Taylor, Lenka A, Arends, Jann, Hodina, Arwen K, Unger, Clemens, Massing, Ulrich
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939842/
https://www.ncbi.nlm.nih.gov/pubmed/17623088
http://dx.doi.org/10.1186/1476-511X-6-17
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author Taylor, Lenka A
Arends, Jann
Hodina, Arwen K
Unger, Clemens
Massing, Ulrich
author_facet Taylor, Lenka A
Arends, Jann
Hodina, Arwen K
Unger, Clemens
Massing, Ulrich
author_sort Taylor, Lenka A
collection PubMed
description BACKGROUND: It has been observed that ras-transformed cell lines in culture have a higher phosphatidylcholine (PC) biosynthesis rate as well as higher PC-degradation rate (increased PC-turnover) than normal cells. In correspondence to these findings, the concentrations of the PC-degradation product lyso-phosphatidylcholine (LPC) in cancer patients were found to be decreased. Our objective was the systematic investigation of the relationship between LPC and inflammatory and nutritional parameters in cancer patients. Therefore, plasma LPC concentrations were assessed in 59 cancer patients and related to nutritional and inflammatory parameters. To determine LPC in blood plasma we developed and validated a HPTLC method. RESULTS: Average plasma LPC concentration was 207 ± 59 μM which corresponds to the lower limit of the reported range in healthy subjects. No correlation between LPC and age, performance status, body mass index (BMI) or fat mass could be seen. However, LPC correlated inversely with plasma C-reactive protein (CRP) and whole blood hydrogen peroxides (HPO). Further, a negative correlation could be observed between LPC and whole body extra cellular fluid volume (ECF) as well as with relative change in body weight since cancer diagnosis. CONCLUSION: In conclusion, LPC concentrations were decreased in cancer patients. LPC plasma concentrations correlated with weight loss and inflammatory parameters and, therefore, might be a general indicator of severity of malignant disease.
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spelling pubmed-19398422007-08-04 Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status Taylor, Lenka A Arends, Jann Hodina, Arwen K Unger, Clemens Massing, Ulrich Lipids Health Dis Research BACKGROUND: It has been observed that ras-transformed cell lines in culture have a higher phosphatidylcholine (PC) biosynthesis rate as well as higher PC-degradation rate (increased PC-turnover) than normal cells. In correspondence to these findings, the concentrations of the PC-degradation product lyso-phosphatidylcholine (LPC) in cancer patients were found to be decreased. Our objective was the systematic investigation of the relationship between LPC and inflammatory and nutritional parameters in cancer patients. Therefore, plasma LPC concentrations were assessed in 59 cancer patients and related to nutritional and inflammatory parameters. To determine LPC in blood plasma we developed and validated a HPTLC method. RESULTS: Average plasma LPC concentration was 207 ± 59 μM which corresponds to the lower limit of the reported range in healthy subjects. No correlation between LPC and age, performance status, body mass index (BMI) or fat mass could be seen. However, LPC correlated inversely with plasma C-reactive protein (CRP) and whole blood hydrogen peroxides (HPO). Further, a negative correlation could be observed between LPC and whole body extra cellular fluid volume (ECF) as well as with relative change in body weight since cancer diagnosis. CONCLUSION: In conclusion, LPC concentrations were decreased in cancer patients. LPC plasma concentrations correlated with weight loss and inflammatory parameters and, therefore, might be a general indicator of severity of malignant disease. BioMed Central 2007-07-10 /pmc/articles/PMC1939842/ /pubmed/17623088 http://dx.doi.org/10.1186/1476-511X-6-17 Text en Copyright © 2007 Taylor et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Taylor, Lenka A
Arends, Jann
Hodina, Arwen K
Unger, Clemens
Massing, Ulrich
Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status
title Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status
title_full Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status
title_fullStr Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status
title_full_unstemmed Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status
title_short Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status
title_sort plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939842/
https://www.ncbi.nlm.nih.gov/pubmed/17623088
http://dx.doi.org/10.1186/1476-511X-6-17
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