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Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons
The role of adult hippocampal neurogenesis in spatial learning remains a matter of debate. Here, we show that spatial learning modifies neurogenesis by inducing a cascade of events that resembles the selective stabilization process characterizing development. Learning promotes survival of relatively...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939885/ https://www.ncbi.nlm.nih.gov/pubmed/17683201 http://dx.doi.org/10.1371/journal.pbio.0050214 |
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author | Dupret, David Fabre, Annabelle Döbrössy, Màtè Dàniel Panatier, Aude Rodríguez, José Julio Lamarque, Stéphanie Lemaire, Valerie Oliet, Stephane H. R Piazza, Pier-Vincenzo Abrous, Djoher Nora |
author_facet | Dupret, David Fabre, Annabelle Döbrössy, Màtè Dàniel Panatier, Aude Rodríguez, José Julio Lamarque, Stéphanie Lemaire, Valerie Oliet, Stephane H. R Piazza, Pier-Vincenzo Abrous, Djoher Nora |
author_sort | Dupret, David |
collection | PubMed |
description | The role of adult hippocampal neurogenesis in spatial learning remains a matter of debate. Here, we show that spatial learning modifies neurogenesis by inducing a cascade of events that resembles the selective stabilization process characterizing development. Learning promotes survival of relatively mature neurons, apoptosis of more immature cells, and finally, proliferation of neural precursors. These are three interrelated events mediating learning. Thus, blocking apoptosis impairs memory and inhibits learning-induced cell survival and cell proliferation. In conclusion, during learning, similar to the selective stabilization process, neuronal networks are sculpted by a tightly regulated selection and suppression of different populations of newly born neurons. |
format | Text |
id | pubmed-1939885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-19398852007-08-14 Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons Dupret, David Fabre, Annabelle Döbrössy, Màtè Dàniel Panatier, Aude Rodríguez, José Julio Lamarque, Stéphanie Lemaire, Valerie Oliet, Stephane H. R Piazza, Pier-Vincenzo Abrous, Djoher Nora PLoS Biol Research Article The role of adult hippocampal neurogenesis in spatial learning remains a matter of debate. Here, we show that spatial learning modifies neurogenesis by inducing a cascade of events that resembles the selective stabilization process characterizing development. Learning promotes survival of relatively mature neurons, apoptosis of more immature cells, and finally, proliferation of neural precursors. These are three interrelated events mediating learning. Thus, blocking apoptosis impairs memory and inhibits learning-induced cell survival and cell proliferation. In conclusion, during learning, similar to the selective stabilization process, neuronal networks are sculpted by a tightly regulated selection and suppression of different populations of newly born neurons. Public Library of Science 2007-08 2007-08-07 /pmc/articles/PMC1939885/ /pubmed/17683201 http://dx.doi.org/10.1371/journal.pbio.0050214 Text en © 2007 Dupret et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Dupret, David Fabre, Annabelle Döbrössy, Màtè Dàniel Panatier, Aude Rodríguez, José Julio Lamarque, Stéphanie Lemaire, Valerie Oliet, Stephane H. R Piazza, Pier-Vincenzo Abrous, Djoher Nora Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons |
title | Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons |
title_full | Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons |
title_fullStr | Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons |
title_full_unstemmed | Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons |
title_short | Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons |
title_sort | spatial learning depends on both the addition and removal of new hippocampal neurons |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939885/ https://www.ncbi.nlm.nih.gov/pubmed/17683201 http://dx.doi.org/10.1371/journal.pbio.0050214 |
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