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Expression of VE-Cadherin in Peritubular Endothelial Cells during Acute Rejection after Human Renal Transplantation
Genes involved in acute rejection (AR) after organ transplantation remain to be further elucidated. In a previous work we have demonstrated the under-expression of VE-Cadherin by endothelial cells (EC) in AR following murine and human heart transplantation. Serial sections from 15 human kidney Banff...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940055/ https://www.ncbi.nlm.nih.gov/pubmed/17710242 http://dx.doi.org/10.1155/2007/41705 |
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author | Roussoulières, Ana McGregor, Brigitte Chalabreysse, Lara Cerutti, Catherine Garnier, Jeanne-Luce Boissonnat, Pascale Bastien, Olivier Scoazec, Jean-Yves Thivolet-Bejui, Françoise Sebbag, Laurent L. McGregor, John |
author_facet | Roussoulières, Ana McGregor, Brigitte Chalabreysse, Lara Cerutti, Catherine Garnier, Jeanne-Luce Boissonnat, Pascale Bastien, Olivier Scoazec, Jean-Yves Thivolet-Bejui, Françoise Sebbag, Laurent L. McGregor, John |
author_sort | Roussoulières, Ana |
collection | PubMed |
description | Genes involved in acute rejection (AR) after organ transplantation remain to be further elucidated. In a previous work we have demonstrated the under-expression of VE-Cadherin by endothelial cells (EC) in AR following murine and human heart transplantation. Serial sections from 15 human kidney Banff-graded transplant biopsies were examined for the presence of VE-Cadherin and CD34 staining by immunohistochemistry (no AR (n = 5), AR grade IA (n = 5), or AR grade IIA (n = 5)). Quantification of peritubular EC staining were evaluated and results were expressed by the percentage of stained cells per surface analysed. There was no difference in CD34 staining between the 3 groups. VE-Cadherin expression was significantly reduced in AR Grade IIA when compared to no AR (P = .01) and to AR grade IA (P = .02). This study demonstrates a reduced VE-Cadherin expression by EC in AR after renal transplantation. The down-regulation of VE-Cadherin may strongly participate in human AR. |
format | Text |
id | pubmed-1940055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-19400552007-08-20 Expression of VE-Cadherin in Peritubular Endothelial Cells during Acute Rejection after Human Renal Transplantation Roussoulières, Ana McGregor, Brigitte Chalabreysse, Lara Cerutti, Catherine Garnier, Jeanne-Luce Boissonnat, Pascale Bastien, Olivier Scoazec, Jean-Yves Thivolet-Bejui, Françoise Sebbag, Laurent L. McGregor, John J Biomed Biotechnol Research Article Genes involved in acute rejection (AR) after organ transplantation remain to be further elucidated. In a previous work we have demonstrated the under-expression of VE-Cadherin by endothelial cells (EC) in AR following murine and human heart transplantation. Serial sections from 15 human kidney Banff-graded transplant biopsies were examined for the presence of VE-Cadherin and CD34 staining by immunohistochemistry (no AR (n = 5), AR grade IA (n = 5), or AR grade IIA (n = 5)). Quantification of peritubular EC staining were evaluated and results were expressed by the percentage of stained cells per surface analysed. There was no difference in CD34 staining between the 3 groups. VE-Cadherin expression was significantly reduced in AR Grade IIA when compared to no AR (P = .01) and to AR grade IA (P = .02). This study demonstrates a reduced VE-Cadherin expression by EC in AR after renal transplantation. The down-regulation of VE-Cadherin may strongly participate in human AR. Hindawi Publishing Corporation 2007 2007-07-26 /pmc/articles/PMC1940055/ /pubmed/17710242 http://dx.doi.org/10.1155/2007/41705 Text en Copyright © 2007 Ana Roussoulières et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Roussoulières, Ana McGregor, Brigitte Chalabreysse, Lara Cerutti, Catherine Garnier, Jeanne-Luce Boissonnat, Pascale Bastien, Olivier Scoazec, Jean-Yves Thivolet-Bejui, Françoise Sebbag, Laurent L. McGregor, John Expression of VE-Cadherin in Peritubular Endothelial Cells during Acute Rejection after Human Renal Transplantation |
title | Expression of VE-Cadherin in Peritubular Endothelial Cells
during Acute Rejection after Human Renal Transplantation |
title_full | Expression of VE-Cadherin in Peritubular Endothelial Cells
during Acute Rejection after Human Renal Transplantation |
title_fullStr | Expression of VE-Cadherin in Peritubular Endothelial Cells
during Acute Rejection after Human Renal Transplantation |
title_full_unstemmed | Expression of VE-Cadherin in Peritubular Endothelial Cells
during Acute Rejection after Human Renal Transplantation |
title_short | Expression of VE-Cadherin in Peritubular Endothelial Cells
during Acute Rejection after Human Renal Transplantation |
title_sort | expression of ve-cadherin in peritubular endothelial cells
during acute rejection after human renal transplantation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940055/ https://www.ncbi.nlm.nih.gov/pubmed/17710242 http://dx.doi.org/10.1155/2007/41705 |
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