Cargando…

Role of Apolipoprotein E in Anxiety

Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve hist...

Descripción completa

Detalles Bibliográficos
Autor principal: Raber, Jacob
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940061/
https://www.ncbi.nlm.nih.gov/pubmed/17710250
http://dx.doi.org/10.1155/2007/91236
_version_ 1782134436235575296
author Raber, Jacob
author_facet Raber, Jacob
author_sort Raber, Jacob
collection PubMed
description Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated signaling and steroidogenesis in the adrenal gland. In addition, human apoE isoforms have differential effects on anxiety in adult mice lacking apoE and probable AD patients. Compared to wild-type mice, mice lacking apoE and apoE4 mice showed pathological alterations in the central nucleus of the amygdala, which is involved in regulation of anxiety. ApoE4, but not mice lacking apoE, or apoE3 mice showed impaired dexamethasone suppression of plasma corticosterone. Understanding how apoE modulates measures of anxiety might help the developments of therapeutic targets to reduce or even prevent measures of anxiety in health and in dementing illnesses.
format Text
id pubmed-1940061
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-19400612007-08-20 Role of Apolipoprotein E in Anxiety Raber, Jacob Neural Plast Review Article Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated signaling and steroidogenesis in the adrenal gland. In addition, human apoE isoforms have differential effects on anxiety in adult mice lacking apoE and probable AD patients. Compared to wild-type mice, mice lacking apoE and apoE4 mice showed pathological alterations in the central nucleus of the amygdala, which is involved in regulation of anxiety. ApoE4, but not mice lacking apoE, or apoE3 mice showed impaired dexamethasone suppression of plasma corticosterone. Understanding how apoE modulates measures of anxiety might help the developments of therapeutic targets to reduce or even prevent measures of anxiety in health and in dementing illnesses. Hindawi Publishing Corporation 2007 2007-07-11 /pmc/articles/PMC1940061/ /pubmed/17710250 http://dx.doi.org/10.1155/2007/91236 Text en Copyright © 2007 Jacob Raber. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Raber, Jacob
Role of Apolipoprotein E in Anxiety
title Role of Apolipoprotein E in Anxiety
title_full Role of Apolipoprotein E in Anxiety
title_fullStr Role of Apolipoprotein E in Anxiety
title_full_unstemmed Role of Apolipoprotein E in Anxiety
title_short Role of Apolipoprotein E in Anxiety
title_sort role of apolipoprotein e in anxiety
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940061/
https://www.ncbi.nlm.nih.gov/pubmed/17710250
http://dx.doi.org/10.1155/2007/91236
work_keys_str_mv AT raberjacob roleofapolipoproteineinanxiety