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Role of Apolipoprotein E in Anxiety
Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve hist...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940061/ https://www.ncbi.nlm.nih.gov/pubmed/17710250 http://dx.doi.org/10.1155/2007/91236 |
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author | Raber, Jacob |
author_facet | Raber, Jacob |
author_sort | Raber, Jacob |
collection | PubMed |
description | Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated signaling and steroidogenesis in the adrenal gland. In addition, human apoE isoforms have differential effects on anxiety in adult mice lacking apoE and probable AD patients. Compared to wild-type mice, mice lacking apoE and apoE4 mice showed pathological alterations in the central nucleus of the amygdala, which is involved in regulation of anxiety. ApoE4, but not mice lacking apoE, or apoE3 mice showed impaired dexamethasone suppression of plasma corticosterone. Understanding how apoE modulates measures of anxiety might help the developments of therapeutic targets to reduce or even prevent measures of anxiety in health and in dementing illnesses. |
format | Text |
id | pubmed-1940061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-19400612007-08-20 Role of Apolipoprotein E in Anxiety Raber, Jacob Neural Plast Review Article Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated signaling and steroidogenesis in the adrenal gland. In addition, human apoE isoforms have differential effects on anxiety in adult mice lacking apoE and probable AD patients. Compared to wild-type mice, mice lacking apoE and apoE4 mice showed pathological alterations in the central nucleus of the amygdala, which is involved in regulation of anxiety. ApoE4, but not mice lacking apoE, or apoE3 mice showed impaired dexamethasone suppression of plasma corticosterone. Understanding how apoE modulates measures of anxiety might help the developments of therapeutic targets to reduce or even prevent measures of anxiety in health and in dementing illnesses. Hindawi Publishing Corporation 2007 2007-07-11 /pmc/articles/PMC1940061/ /pubmed/17710250 http://dx.doi.org/10.1155/2007/91236 Text en Copyright © 2007 Jacob Raber. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Raber, Jacob Role of Apolipoprotein E in Anxiety |
title | Role of Apolipoprotein E in Anxiety |
title_full | Role of Apolipoprotein E in Anxiety |
title_fullStr | Role of Apolipoprotein E in Anxiety |
title_full_unstemmed | Role of Apolipoprotein E in Anxiety |
title_short | Role of Apolipoprotein E in Anxiety |
title_sort | role of apolipoprotein e in anxiety |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940061/ https://www.ncbi.nlm.nih.gov/pubmed/17710250 http://dx.doi.org/10.1155/2007/91236 |
work_keys_str_mv | AT raberjacob roleofapolipoproteineinanxiety |