Cargando…

A Screen for Suppressors of Gross Chromosomal Rearrangements Identifies a Conserved Role for PLP in Preventing DNA Lesions

Genome instability is a hallmark of cancer cells. One class of genome aberrations prevalent in tumor cells is termed gross chromosomal rearrangements (GCRs). GCRs comprise chromosome translocations, amplifications, inversions, deletion of whole chromosome arms, and interstitial deletions. Here, we r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kanellis, Pamela, Gagliardi, Mark, Banath, Judit P, Szilard, Rachel K, Nakada, Shinichiro, Galicia, Sarah, Sweeney, Frederic D, Cabelof, Diane C, Olive, Peggy L, Durocher, Daniel
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1941753/ https://www.ncbi.nlm.nih.gov/pubmed/17696614 http://dx.doi.org/10.1371/journal.pgen.0030134

Ejemplares similares

NPM1 Deletion Is Associated with Gross Chromosomal Rearrangements in Leukemia
por: La Starza, Roberta, et al.
Publicado: (2010)

Effect of prolonging radiation delivery time on retention of gammaH2AX
por: Moiseenko, Vitali, et al.
Publicado: (2008)

Ploidy influences cellular responses to gross chromosomal rearrangements in saccharomyces cerevisiae
por: Jung, Paul P, et al.
Publicado: (2011)

Complex Genomic Rearrangements at the PLP1 Locus Include Triplication and Quadruplication
por: Beck, Christine R., et al.
Publicado: (2015)

Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements
por: Mohebi, Saed, et al.
Publicado: (2015)

Gross Chromosomal Rearrangements in Kluyveromyces marxianus Revealed by Illumina and Oxford Nanopore Sequencing
por: Ding, Lin, et al.
Publicado: (2020)

Generation of Gross Chromosomal Rearrangements by a Single Engineered DNA Double Strand Break
por: Qiu, Zhijun, et al.
Publicado: (2017)

Palindrome-Mediated Translocations in Humans: A New Mechanistic Model for Gross Chromosomal Rearrangements
por: Inagaki, Hidehito, et al.
Publicado: (2016)

Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination
por: Banerjee, Soma, et al.
Publicado: (2008)

Spt2p Defines a New Transcription-Dependent Gross Chromosomal Rearrangement Pathway
por: Sikdar, Nilabja, et al.
Publicado: (2008)

Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription
por: Okita, Akiko K., et al.
Publicado: (2019)

Residual γH2AX foci as an indication of lethal DNA lesions
por: Banáth, Judit P, et al.
Publicado: (2010)

PLP-Dependent Enzymes
por: Paiardini, Alessandro, et al.
Publicado: (2014)

Conformational change of organic cofactor PLP is essential for catalysis in PLP-dependent enzymes
por: Ngo, Ho-Phuong-Thuy, et al.
Publicado: (2022)

Molecular Genetic Analysis of the PLP1 Gene in 38 Families with PLP1-related disorders: Identification and Functional Characterization of 11 Novel PLP1 Mutations
por: Grossi, Serena, et al.
Publicado: (2011)

DNA replication machinery prevents Rad52-dependent single-strand annealing that leads to gross chromosomal rearrangements at centromeres
por: Onaka, Atsushi T., et al.
Publicado: (2020)

Effects of Intron 1 Sequences on Human PLP1 Expression: Implications for PLP1-Related Disorders
por: Wight, Patricia A.
Publicado: (2017)

Telomere-binding proteins Taz1 and Rap1 regulate DSB repair and suppress gross chromosomal rearrangements in fission yeast
por: Irie, Hiroyuki, et al.
Publicado: (2019)

Characterization of gross genome rearrangements in Deinococcus radiodurans recA mutants
por: Repar, Jelena, et al.
Publicado: (2021)

Stimulation of Gross Chromosomal Rearrangements by the Human CEB1 and CEB25 Minisatellites in Saccharomyces cerevisiae Depends on G-Quadruplexes or Cdc13
por: Piazza, Aurèle, et al.
Publicado: (2012)

Distinct patterns of complex rearrangements and a mutational signature of microhomeology are frequently observed in PLP1 copy number gain structural variants
por: Bahrambeigi, Vahid, et al.
Publicado: (2019)

PLP helps the mother centrosome stay mum
por: Short, Ben
Publicado: (2013)

Structural Basis for Allostery in PLP-dependent Enzymes
por: Tran, Jenny U., et al.
Publicado: (2022)

Novel PLP1 Mutations Identified With Next-Generation Sequencing Expand the Spectrum of PLP1-Associated Leukodystrophy Clinical Phenotypes
por: Margraf, Rebecca L., et al.
Publicado: (2018)

MiR-765 functions as a tumour suppressor and eliminates lipids in clear cell renal cell carcinoma by downregulating PLP2
por: Xiao, Wen, et al.
Publicado: (2020)

Correlation Between Anti-Myelin Proteolipid Protein (PLP) Antibodies and Disease Severity in Multiple Sclerosis Patients With PLP Response-Permissive HLA Types
por: Greer, Judith M., et al.
Publicado: (2020)

Engineering chromosome rearrangements in cancer
por: Alonso, Salvador, et al.
Publicado: (2021)

Identification of recurrent 3q13.31 chromosomal rearrangement indicates LSAMP as a tumor suppressor gene in neuroblastoma
por: Martinez-Monleon, Angela, et al.
Publicado: (2023)

In Silico Perspectives on the Prediction of the PLP’s Epitopes involved in Multiple Sclerosis
por: Zamanzadeh, Zahra, et al.
Publicado: (2017)

Antigen presentation by human autoreactive PLP specific T-cell clones
por: Correale, J., et al.
Publicado: (1994)

The Effect of Visible Light on the Catalytic Activity of PLP‐Dependent Enzymes
por: Gerlach, Tim, et al.
Publicado: (2021)

Chromosomal rearrangements in cattle and pigs revealed by chromosome microdissection and chromosome painting
por: Pinton, Alain, et al.
Publicado: (2003)

Molecular heterogeneity of plpE gene in Indian isolates of Pasteurella multocida and expression of recombinant PlpE in vaccine strain of P. multocida serotype B: 2
por: Singh, Ajay Pratap, et al.
Publicado: (2010)

Treatment of phantom limb pain (PLP) based on augmented reality and gaming controlled by myoelectric pattern recognition: a case study of a chronic PLP patient
por: Ortiz-Catalan, Max, et al.
Publicado: (2014)

Folate and Colorectal Cancer in Rodents: A Model of DNA Repair Deficiency
por: Rosati, Rita, et al.
Publicado: (2012)

Immunoregulatory Cell Depletion Improves the Efficacy of Photodynamic Therapy-Generated Cancer Vaccines
por: Korbelik, Mladen, et al.
Publicado: (2015)

Metabolic compensation constrains the temperature dependence of gross primary production
por: Padfield, Daniel, et al.
Publicado: (2017)

Chromosome rearrangements in synovial chondromatous lesions.
por: Mertens, F., et al.
Publicado: (1996)

Mechanisms of chromosomal rearrangement in the human genome
por: Tsai, Albert G, et al.
Publicado: (2010)

On the spot: very local chromosomal rearrangements
por: Helsmoortel, Céline, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_1p3211gtg1gkr127gaq7fkes18