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Candidate Genes for Expansion and Transformation of Hematopoietic Stem Cells by NUP98-HOX Fusion Genes

BACKGROUND: Hox genes are implicated in hematopoietic stem cell (HSC) regulation as well as in leukemia development through translocation with the nucleoporin gene NUP98. Interestingly, an engineered NUP98-HOXA10 (NA10) fusion can induce a several hundred-fold expansion of HSCs in vitro and NA10 and...

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Detalles Bibliográficos
Autores principales:	Palmqvist, Lars, Pineault, Nicolas, Wasslavik, Carina, Humphries, R. Keith
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1942085/ https://www.ncbi.nlm.nih.gov/pubmed/17712416 http://dx.doi.org/10.1371/journal.pone.0000768

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