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Structural Basis of PP2A Inhibition by Small t Antigen

The SV40 small t antigen (ST) is a potent oncoprotein that perturbs the function of protein phosphatase 2A (PP2A). ST directly interacts with the PP2A scaffolding A subunit and alters PP2A activity by displacing regulatory B subunits from the A subunit. We have determined the crystal structure of fu...

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Detalles Bibliográficos
Autores principales:	Cho, Uhn Soo, Morrone, Seamus, Sablina, Anna A, Arroyo, Jason D, Hahn, William C, Xu, Wenqing
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1945078/ https://www.ncbi.nlm.nih.gov/pubmed/17608567 http://dx.doi.org/10.1371/journal.pbio.0050202

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