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Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex

BACKGROUND: The positive transcription elongation factor, P-TEFb, comprised of cyclin dependent kinase 9 (Cdk9) and cyclin T1, T2 or K regulates the productive elongation phase of RNA polymerase II (Pol II) dependent transcription of cellular and integrated viral genes. P-TEFb containing cyclin T1 i...

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Detalles Bibliográficos
Autores principales:	Biglione, Sebastian, Byers, Sarah A, Price, Jason P, Nguyen, Van Trung, Bensaude, Olivier, Price, David H, Maury, Wendy
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1948018/ https://www.ncbi.nlm.nih.gov/pubmed/17625008 http://dx.doi.org/10.1186/1742-4690-4-47

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