Cargando…
Insights from Amphioxus into the Evolution of Vertebrate Cartilage
Central to the story of vertebrate evolution is the origin of the vertebrate head, a problem difficult to approach using paleontology and comparative morphology due to a lack of unambiguous intermediate forms. Embryologically, much of the vertebrate head is derived from two ectodermal tissues, the n...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950077/ https://www.ncbi.nlm.nih.gov/pubmed/17726517 http://dx.doi.org/10.1371/journal.pone.0000787 |
_version_ | 1782134528063569920 |
---|---|
author | Meulemans, Daniel Bronner-Fraser, Marianne |
author_facet | Meulemans, Daniel Bronner-Fraser, Marianne |
author_sort | Meulemans, Daniel |
collection | PubMed |
description | Central to the story of vertebrate evolution is the origin of the vertebrate head, a problem difficult to approach using paleontology and comparative morphology due to a lack of unambiguous intermediate forms. Embryologically, much of the vertebrate head is derived from two ectodermal tissues, the neural crest and cranial placodes. Recent work in protochordates suggests the first chordates possessed migratory neural tube cells with some features of neural crest cells. However, it is unclear how and when these cells acquired the ability to form cellular cartilage, a cell type unique to vertebrates. It has been variously proposed that the neural crest acquired chondrogenic ability by recruiting proto-chondrogenic gene programs deployed in the neural tube, pharynx, and notochord. To test these hypotheses we examined the expression of 11 amphioxus orthologs of genes involved in neural crest chondrogenesis. Consistent with cellular cartilage as a vertebrate novelty, we find that no single amphioxus tissue co-expresses all or most of these genes. However, most are variously co-expressed in mesodermal derivatives. Our results suggest that neural crest-derived cartilage evolved by serial cooption of genes which functioned primitively in mesoderm. |
format | Text |
id | pubmed-1950077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-19500772007-08-29 Insights from Amphioxus into the Evolution of Vertebrate Cartilage Meulemans, Daniel Bronner-Fraser, Marianne PLoS One Research Article Central to the story of vertebrate evolution is the origin of the vertebrate head, a problem difficult to approach using paleontology and comparative morphology due to a lack of unambiguous intermediate forms. Embryologically, much of the vertebrate head is derived from two ectodermal tissues, the neural crest and cranial placodes. Recent work in protochordates suggests the first chordates possessed migratory neural tube cells with some features of neural crest cells. However, it is unclear how and when these cells acquired the ability to form cellular cartilage, a cell type unique to vertebrates. It has been variously proposed that the neural crest acquired chondrogenic ability by recruiting proto-chondrogenic gene programs deployed in the neural tube, pharynx, and notochord. To test these hypotheses we examined the expression of 11 amphioxus orthologs of genes involved in neural crest chondrogenesis. Consistent with cellular cartilage as a vertebrate novelty, we find that no single amphioxus tissue co-expresses all or most of these genes. However, most are variously co-expressed in mesodermal derivatives. Our results suggest that neural crest-derived cartilage evolved by serial cooption of genes which functioned primitively in mesoderm. Public Library of Science 2007-08-29 /pmc/articles/PMC1950077/ /pubmed/17726517 http://dx.doi.org/10.1371/journal.pone.0000787 Text en Meulemans, Bronner-Fraser. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Meulemans, Daniel Bronner-Fraser, Marianne Insights from Amphioxus into the Evolution of Vertebrate Cartilage |
title | Insights from Amphioxus into the Evolution of Vertebrate Cartilage |
title_full | Insights from Amphioxus into the Evolution of Vertebrate Cartilage |
title_fullStr | Insights from Amphioxus into the Evolution of Vertebrate Cartilage |
title_full_unstemmed | Insights from Amphioxus into the Evolution of Vertebrate Cartilage |
title_short | Insights from Amphioxus into the Evolution of Vertebrate Cartilage |
title_sort | insights from amphioxus into the evolution of vertebrate cartilage |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950077/ https://www.ncbi.nlm.nih.gov/pubmed/17726517 http://dx.doi.org/10.1371/journal.pone.0000787 |
work_keys_str_mv | AT meulemansdaniel insightsfromamphioxusintotheevolutionofvertebratecartilage AT bronnerfrasermarianne insightsfromamphioxusintotheevolutionofvertebratecartilage |