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Associations between mild-to-moderate anaemia in pregnancy and helminth, malaria and HIV infection in Entebbe, Uganda
It is suggested that helminths, particularly hookworm and schistosomiasis, may be important causes of anaemia in pregnancy. We assessed the associations between mild-to-moderate anaemia (haemoglobin >8.0 g/dl and <11.2 g/dl) and helminths, malaria and HIV among 2507 otherwise healthy pregnant...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950430/ https://www.ncbi.nlm.nih.gov/pubmed/17555783 http://dx.doi.org/10.1016/j.trstmh.2007.03.017 |
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author | Muhangi, Lawrence Woodburn, Patrick Omara, Mildred Omoding, Nicholas Kizito, Dennison Mpairwe, Harriet Nabulime, Juliet Ameke, Christine Morison, Linda A. Elliott, Alison M. |
author_facet | Muhangi, Lawrence Woodburn, Patrick Omara, Mildred Omoding, Nicholas Kizito, Dennison Mpairwe, Harriet Nabulime, Juliet Ameke, Christine Morison, Linda A. Elliott, Alison M. |
author_sort | Muhangi, Lawrence |
collection | PubMed |
description | It is suggested that helminths, particularly hookworm and schistosomiasis, may be important causes of anaemia in pregnancy. We assessed the associations between mild-to-moderate anaemia (haemoglobin >8.0 g/dl and <11.2 g/dl) and helminths, malaria and HIV among 2507 otherwise healthy pregnant women at enrolment to a trial of deworming in pregnancy in Entebbe, Uganda. The prevalence of anaemia was 39.7%. The prevalence of hookworm was 44.5%, Mansonella perstans 21.3%, Schistosoma mansoni 18.3%, Strongyloides 12.3%, Trichuris 9.1%, Ascaris 2.3%, asymptomatic Plasmodium falciparum parasitaemia 10.9% and HIV 11.9%. Anaemia showed little association with the presence of any helminth, but showed a strong association with malaria (adjusted odds ratio (AOR) 3.22, 95% CI 2.43–4.26) and HIV (AOR 2.46, 95% CI 1.90–3.19). There was a weak association between anaemia and increasing hookworm infection intensity. Thus, although highly prevalent, helminths showed little association with mild-to-moderate anaemia in this population, but HIV and malaria both showed a strong association. This result may relate to relatively good nutrition and low helminth infection intensity. These findings are pertinent to estimating the disease burden of helminths and other infections in pregnancy. [Clinical Trial No. ISRCTN32849447] |
format | Text |
id | pubmed-1950430 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-19504302007-08-30 Associations between mild-to-moderate anaemia in pregnancy and helminth, malaria and HIV infection in Entebbe, Uganda Muhangi, Lawrence Woodburn, Patrick Omara, Mildred Omoding, Nicholas Kizito, Dennison Mpairwe, Harriet Nabulime, Juliet Ameke, Christine Morison, Linda A. Elliott, Alison M. Trans R Soc Trop Med Hyg Article It is suggested that helminths, particularly hookworm and schistosomiasis, may be important causes of anaemia in pregnancy. We assessed the associations between mild-to-moderate anaemia (haemoglobin >8.0 g/dl and <11.2 g/dl) and helminths, malaria and HIV among 2507 otherwise healthy pregnant women at enrolment to a trial of deworming in pregnancy in Entebbe, Uganda. The prevalence of anaemia was 39.7%. The prevalence of hookworm was 44.5%, Mansonella perstans 21.3%, Schistosoma mansoni 18.3%, Strongyloides 12.3%, Trichuris 9.1%, Ascaris 2.3%, asymptomatic Plasmodium falciparum parasitaemia 10.9% and HIV 11.9%. Anaemia showed little association with the presence of any helminth, but showed a strong association with malaria (adjusted odds ratio (AOR) 3.22, 95% CI 2.43–4.26) and HIV (AOR 2.46, 95% CI 1.90–3.19). There was a weak association between anaemia and increasing hookworm infection intensity. Thus, although highly prevalent, helminths showed little association with mild-to-moderate anaemia in this population, but HIV and malaria both showed a strong association. This result may relate to relatively good nutrition and low helminth infection intensity. These findings are pertinent to estimating the disease burden of helminths and other infections in pregnancy. [Clinical Trial No. ISRCTN32849447] Oxford University Press 2007-09 /pmc/articles/PMC1950430/ /pubmed/17555783 http://dx.doi.org/10.1016/j.trstmh.2007.03.017 Text en . https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. |
spellingShingle | Article Muhangi, Lawrence Woodburn, Patrick Omara, Mildred Omoding, Nicholas Kizito, Dennison Mpairwe, Harriet Nabulime, Juliet Ameke, Christine Morison, Linda A. Elliott, Alison M. Associations between mild-to-moderate anaemia in pregnancy and helminth, malaria and HIV infection in Entebbe, Uganda |
title | Associations between mild-to-moderate anaemia in pregnancy and helminth, malaria and HIV infection in Entebbe, Uganda |
title_full | Associations between mild-to-moderate anaemia in pregnancy and helminth, malaria and HIV infection in Entebbe, Uganda |
title_fullStr | Associations between mild-to-moderate anaemia in pregnancy and helminth, malaria and HIV infection in Entebbe, Uganda |
title_full_unstemmed | Associations between mild-to-moderate anaemia in pregnancy and helminth, malaria and HIV infection in Entebbe, Uganda |
title_short | Associations between mild-to-moderate anaemia in pregnancy and helminth, malaria and HIV infection in Entebbe, Uganda |
title_sort | associations between mild-to-moderate anaemia in pregnancy and helminth, malaria and hiv infection in entebbe, uganda |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950430/ https://www.ncbi.nlm.nih.gov/pubmed/17555783 http://dx.doi.org/10.1016/j.trstmh.2007.03.017 |
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