V3 Loop Truncations in HIV-1 Envelope Impart Resistance to Coreceptor Inhibitors and Enhanced Sensitivity to Neutralizing Antibodies

The V1/V2 region and the V3 loop of the human immunodeficiency virus type I (HIV-1) envelope (Env) protein are targets for neutralizing antibodies and also play an important functional role, with the V3 loop largely determining whether a virus uses CCR5 (R5), CXCR4 (X4), or either coreceptor (R5X4)...

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Detalles Bibliográficos
Autores principales: Laakso, Meg M, Lee, Fang-Hua, Haggarty, Beth, Agrawal, Caroline, Nolan, Katrina M, Biscone, Mark, Romano, Josephine, Jordan, Andrea P. O, Leslie, George J, Meissner, Eric G, Su, Lishan, Hoxie, James A, Doms, Robert W
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950945/
https://www.ncbi.nlm.nih.gov/pubmed/17722977
http://dx.doi.org/10.1371/journal.ppat.0030117

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