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Late Endosomal Cholesterol Accumulation Leads to Impaired Intra-Endosomal Trafficking
BACKGROUND: Pathological accumulation of cholesterol in late endosomes is observed in lysosomal storage diseases such as Niemann-Pick type C. We here analyzed the effects of cholesterol accumulation in NPC cells, or as phenocopied by the drug U18666A, on late endosomes membrane organization and dyna...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952175/ https://www.ncbi.nlm.nih.gov/pubmed/17786222 http://dx.doi.org/10.1371/journal.pone.0000851 |