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Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an Aβ-Degrading Protease: A Novel Therapeutic Approach to Alzheimer Disease

BACKGROUND: Understanding the mechanisms of amyloid-β protein (Aβ) production and clearance in the brain has been essential to elucidating the etiology of Alzheimer disease (AD). Chronically decreasing brain Aβ levels is an emerging therapeutic approach for AD, but no such disease-modifying agents h...

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Detalles Bibliográficos
Autores principales:	Hemming, Matthew L, Patterson, Michaela, Reske-Nielsen, Casper, Lin, Ling, Isacson, Ole, Selkoe, Dennis J
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952204/ https://www.ncbi.nlm.nih.gov/pubmed/17760499 http://dx.doi.org/10.1371/journal.pmed.0040262

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